지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제37권 제8호
- 발행연도
- 2014.1
- 수록면
- 967 - 971 (5page)
이용수
초록· 키워드
오류제보하기
The elucidation of the structures of complex natural products bearing many quaternary carbons remains challenging, even in this advanced spectroscopic era. $^{13}C-^{13}C$ COSY NMR spectroscopy shows direct couplings between $^{13}C$ and $^{13}C$, which comprise the backbone of a natural product. Thus, this type of experiment is particularly useful for natural products bearing consecutive quaternary carbons. However, the low sensitivity of $^{13}C$-based NMR experiments, due to the low natural abundance of the $^{13}C$ nucleus, is problematic when applying these techniques. Our efforts in the $^{13}C$ labeling of a microbial natural product, cyclopiazonic acid (1), by feeding $^{13}C$-labeled glucose to the fungal culture, enabled us to acquire $^{13}C-^{13}C$ COSY NMR spectra on a milligram scale that clearly show the carbon backbone of the compound. This is the first application of $^{13}C-^{13}C$ COSY NMR experiments for a natural product. The results suggest that $^{13}C-^{13}C$ COSY NMR spectroscopy can be routinely used for the structure determination of microbial natural products by $^{13}C$-enrichment of a compound with $^{13}C$-glucose.
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