지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제37권 제2호
- 발행연도
- 2014.1
- 수록면
- 186 - 192 (7page)
이용수
초록· 키워드
오류제보하기
Radix Astragali (Astragalus membranaceus) is an important traditional Chinese medicine that is widely used as a tonic to enhance the body's natural defense mechanisms. In this phytochemical study, 12 flavonoids, isoliquiritigenin (1), liquiritigenin (2), calycosin (3), calycosin 7-O-${\beta}$-$\small{D}$-glucoside (4), formononetin (5), formononetin 7-O-${\beta}$-$\small{D}$-glucoside (6), daidzein (7), daidzein 7-O-${\beta}$-$\small{D}$-glucoside (8), methylnissolin (9), methylnissolin 3-O-${\beta}$-$\small{D}$-glucoside (10), isomucronulatol (11), and isomucronulatol 7-O-${\beta}$-$\small{D}$-glucoside (12), were isolated from the roots of A. membranaceus. Their structures were elucidated by comparing spectroscopic data with reported values. The effects of the isolated compounds on lipopolysaccharide (LPS)-stimulated bone marrow-derived dendritic cells were investigated. Compounds 1 and 2 exhibited significant inhibitory effects on LPS-induced IL-6 and IL-12 p40 production, with $IC_{50}$ values ranging from 2.7 to $6.1{\mu}M$. Compound 1 also showed a moderate inhibitory effect on LPS-stimulated production of TNF-${\alpha}$ with an $IC_{50}$ value of $20.1{\mu}M$. Further studies of the potential anti-inflammatory effects and benefits of flavonoids from A. membranaceus are warranted.
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