지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Objectives The second to fourth digit ratio (2D : 4D) is known to reflect testosterone level during intrauterine period. Testosterone is essential for masculinization of brain. Cloninger's type II alcoholism is characterized by early age at onset and largely limited to males. Compared with type I alcoholism, type II alcoholism is thought to be masculine. There is a possibility that the digit ratio of type II alcoholism is low compared with type I. We examined digit length ratio in Cloninger's type I and II alcoholism to understand the effects of intrauterine testosterone on the development of alcoholism. Methods The participants were 87 alcohol dependent patients. We divided two subtypes of patients by Irwin's symptom list, based on Cloninger's concept. We captured the images of both palms by the scanner and measured the lengths of digits by the graphic program. Then we analyzed the digit ratios by independent-sample t-test. Results The mean 2D : 4D of type I was 0.942 (right), 0.952 (left). The mean 2D : 4D of type II was 0.927 (right), 0.940 (left). In both hands, 2D : 4D of type II was significantly lower than type I. Conclusions Type II alcoholism showed masculine type of digit length ratio compared with type I. It suggests the exposure of testosterone during intrauterine period might play an important role in determining the course and feature of alcoholism.
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참고문헌 (48)
참고문헌 신청
American Psychiatric Association / 1994 / Diagnostic and statistical manual of mental disorders. 4th ed / American Psychiatric Association
Irwin M / 1990 / Clinical importance of age at onset in type 1 and type 2 primary alcoholics / Arch Gen Psychiatry 47:320~324
Mayfield RD / 2008 / Genetic factors influencing alcohol dependence / Br J Pharmacol 154:275~287
Schuckit MA / 2000 / Genetics of the risk for alcoholism / Am J Addict 9:103~112
Prescott CA / 1999 / Sex differences in the sources of genetic liability to alcohol abuse and dependence in a population- based sample of U.S. twins / Alcohol Clin Exp Res 23:1136~1144
Irwin M / 1990 / Clinical importance of age at onset in type 1 and type 2 primary alcoholics / Arch Gen Psychiatry 47:320~324
Mayfield RD / 2008 / Genetic factors influencing alcohol dependence / Br J Pharmacol 154:275~287
Schuckit MA / 2000 / Genetics of the risk for alcoholism / Am J Addict 9:103~112
Prescott CA / 1999 / Sex differences in the sources of genetic liability to alcohol abuse and dependence in a population- based sample of U.S. twins / Alcohol Clin Exp Res 23:1136~1144
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