지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Normal aging causes changes in the brain volume, connection, function and cognition. The brain changes with increases in age and difference of gender varies at all levels. Studies about normal brain aging using various brain magnetic resonance imaging (MRI) variables such as gray and white matter structural imaging, proton spectroscopy, apparent diffusion coefficient, diffusion tensor imaging and functional MRI are reviewed. Total volume of brain increases after birth but decreases after 9 years old. During adulthood, total volume of brain is relatively stable. After 35 years old, brain shrinks gradually. The changes of gray and white matters by aging show different features. N-acetylaspartate decreases or remains unchanged but choline, creatine and myo-inositol increase with aging. Apparent diffusion coefficient decreases till 20 years old and then becomes stable during adulthood and increase after 60 years old. Diffusion tensor properties in white matter tissue are variable during aging. Resting-state functional connectivity decreases after middle age. Structural and functional brain changes with normal aging are important for studying various psychiatric diseases such as dementia, schizophrenia and bipolar disorder. Our review may be helpful for studying longitudinal changes of these diseases and successful aging.
목차
등록된 정보가 없습니다.
참고문헌 (128)
참고문헌 신청
Statistics Korea / 2011 / 2010 Population and housing census report:based on complete enumeration
Mora F / 2013 / Successful brain aging : plasticity, environmental enrichment, and lifestyle / Dialogues Clin Neurosci 15:45~52
Nasrallah HA / 1986 / The Neurology of Schizophrenia / Elsevier
Walker J / 2002 / Schizophrenia and bipolar disorder:similarities in pathogenic mechanisms but differences in neurodevelopment / Int Clin Psychopharmacol 17(Suppl 3):S11~S19
Dekaban AS / 1978 / Changes in brain weights during the span of human life : relation of brain weights to body heights and body weights / Ann Neurol 4:345~356
Mora F / 2013 / Successful brain aging : plasticity, environmental enrichment, and lifestyle / Dialogues Clin Neurosci 15:45~52
Nasrallah HA / 1986 / The Neurology of Schizophrenia / Elsevier
Walker J / 2002 / Schizophrenia and bipolar disorder:similarities in pathogenic mechanisms but differences in neurodevelopment / Int Clin Psychopharmacol 17(Suppl 3):S11~S19
Dekaban AS / 1978 / Changes in brain weights during the span of human life : relation of brain weights to body heights and body weights / Ann Neurol 4:345~356
이 논문의 저자 정보
최근 본 자료
댓글(0)
0