지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Objectives Optimized voxel based morphometry (VBM) has been increasingly applied to investigate differences in the brain morphology between a group of patients with mild cognitive impairment (MCI) and control subjects. Optimized VBM permits comparison of gray matter (GM) volume at voxel-level from the entire brain. The purpose of this study was to assess the regional GM volume change measured by optimized VBM in MCI subjects compared to controls. Methods Twenty patients with MCI and 20 control subjects with normal cognition were recruited for this study. We applied the optimized VBM protocol to the image data including study-specific template and the modulation of the data with the Jacobian determinants. GM volume differences between the MCI subjects and the control subjects and their correlations with the neuropsychological performances were investigated. Results Optimized VBM analysis revealed GM volume reduction in hippocampus, precentral gyrus, insula and parietal operculum in the MCI group compared to the control group (family wise error corrected p < 0.05). Korean version of the Consortium to Establish a Registry for Alzheimer's disease (CERAD-K) word list recall scores were significantly correlated with the GM volumes of hippocampus, precuneus and posterior cingulate in the MCI group (FWE corrected p < 0.05). Conclusions The results confirm previous findings of atrophic changes in medial temporal lobe and parietal lobe in the MCI group and suggest that these abnormalities may be related with cognitive decline and prognosis in patients with MCI.
목차
등록된 정보가 없습니다.
참고문헌 (32)
참고문헌 신청
Petersen RC / 2009 / Mild cognitive impairment: ten years later / Arch Neurol 66:1447~1455
Linn RT / 1995 / The ‘preclinical phase’ of probable Alzheimer’s disease / Arch Neurol 52:485~490
Ries ML / 2008 / Magnetic resonance imaging characterization of brain structure and function in mild cognitive impairment: a review / J Am Geriatr Soc 56:920~934
Stoub TR / 2006 / Hippocampal disconnection contributes to memory dysfunction in individuals at risk for Alzheimer’s disease / Proc Natl Acad Sci U S A 103:10041~10045
Becker JT / 2006 / Three-dimensional patterns of hippocampal atrophy in mild cognitive impairment / Arch Neurol 63:97~101
Linn RT / 1995 / The ‘preclinical phase’ of probable Alzheimer’s disease / Arch Neurol 52:485~490
Ries ML / 2008 / Magnetic resonance imaging characterization of brain structure and function in mild cognitive impairment: a review / J Am Geriatr Soc 56:920~934
Stoub TR / 2006 / Hippocampal disconnection contributes to memory dysfunction in individuals at risk for Alzheimer’s disease / Proc Natl Acad Sci U S A 103:10041~10045
Becker JT / 2006 / Three-dimensional patterns of hippocampal atrophy in mild cognitive impairment / Arch Neurol 63:97~101
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