지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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Objectives Prenatal testosterone is known to influence both cerebral laterality and 2nd to 4th digit ratio (2D : 4D). Epigenetic changes are thought to play some role in it. We studied sex-related differences between 2D : 4D and cerebral laterality in patients with schizophrenia and controls to examine the effects of prenatal testosterone in the development of schizophrenia. Methods Forty one men (18 schizophrenic patients and 23 controls) and 40 women (17 schizophrenic patients and 23 controls) were recruited from one psychiatric hospital in Korea. The 2D : 4D and electroencephalographic (EEG) coherence in 19 channels (66 pairs of interhemispheric coherence and 54 pairs of intrahemispheric coherence) were measured. The sex-related statistical analyses between 2D : 4D and EEG coherence in controls and patients with schizophrenia were performed using multiple regression. Results In male patients, the relationship between 2D : 4D and right intrahemispheric EEG coherence showed mainly positive correlation in delta and theta frequency bands, while it showed negative correlation in male controls. In female patients, the relationship between 2D : 4D and interhemispheric EEG coherence showed stronger positive correlation in alpha and beta frequency bands, while it showed weaker positive correlation in female controls. Conclusions Low prenatal testosterone may play certain roles in altered correlation between 2D : 4D and cerebral laterality in schizophrenia and the development of schizophrenia by epigenetic mechanism.
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참고문헌 (56)
참고문헌 신청
Rodenhiser D / 2006 / Epigenetics and human disease : translating basic biology into clinical applications / CMAJ 174:341~348
St Clair D / 2005 / Rates of adult schizophrenia following prenatal exposure to the Chinese famine of 1959-1961 / JAMA 294:557~562
Petronis A / 2001 / Human morbid genetics revisited : relevance of epigenetics / Trends Genet 17:142~146
Murray EK / 2009 / Epigenetic control of sexual differentiation of the bed nucleus of the stria terminalis / Endocrinology 150:4241~4247
Manning JT / 2002 / Digit ratio: a pointer to fertility, behavior, and health / Rutgers University Press
St Clair D / 2005 / Rates of adult schizophrenia following prenatal exposure to the Chinese famine of 1959-1961 / JAMA 294:557~562
Petronis A / 2001 / Human morbid genetics revisited : relevance of epigenetics / Trends Genet 17:142~146
Murray EK / 2009 / Epigenetic control of sexual differentiation of the bed nucleus of the stria terminalis / Endocrinology 150:4241~4247
Manning JT / 2002 / Digit ratio: a pointer to fertility, behavior, and health / Rutgers University Press
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