지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Objectives The aim of this study was to assess variations in caudate volume according to dopamin receptor D2/ankyin repeat and kinase domain containing 1 (DRD2/ANKK1) Taq 1a polymorphisms in young healthy adults and to evaluate the relationship between caudate volumes and psychiatric symptoms as measured by the Brief Psychiatric Rating Scale. Methods Genetic information regarding DRD2/ANKK1 Taq 1a and T1-weighted brain magnetic resonance images were acquired from 30 young healthy adults. Automatic segmentation of caudate was performed using the FreeSurfer program. Results Individuals with A2 homozygotes of DRD2/ANKK1 Taq 1a polymorphisms (n = 10) had greater right caudate volumes compared to those with A1 allele (s)(18.4% greater ; p = 0.019). Right caudate volumes were negatively associated with total scores of the Brief Psychiatric Rating Scale (${\beta}$=-0.50 ; p = 0.016). Conclusions Our findings suggest the possibility that DRD2/ANKK1 Taq 1a polymorphisms may underlie the psychiatric symptoms by influencing the structure of the right caudate.
목차
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참고문헌 (29)
참고문헌 신청
Comings DE / 1991 / The dopamine D2 receptor locus as a modifying gene in neuropsychiatric disorders / JAMA 266:1793~1800
Noble EP / 2003 / D2 dopamine receptor gene in psychiatric and neurologic disorders and its phenotypes / Am J Med Genet B Neuropsychiatr Genet 116B:103~125
Thompson J / 1997 / D2 dopamine receptor gene (DRD2) Taq1 A polymorphism: reduced dopamine D2 receptor binding in the human striatum associated with the A1 allele / Pharmacogenetics 7:479~484
Pohjalainen T / 1998 / The A1 allele of the human D2 dopamine receptor gene predicts low D2 receptor availability in healthy volunteers / Mol Psychiatry 3:256~260
JÖnsson EG / 1999 / Polymorphisms in the dopamine D2 receptor gene and their relationships to striatal dopamine receptor density of healthy volunteers / Mol Psychiatry 4:290~296
Noble EP / 2003 / D2 dopamine receptor gene in psychiatric and neurologic disorders and its phenotypes / Am J Med Genet B Neuropsychiatr Genet 116B:103~125
Thompson J / 1997 / D2 dopamine receptor gene (DRD2) Taq1 A polymorphism: reduced dopamine D2 receptor binding in the human striatum associated with the A1 allele / Pharmacogenetics 7:479~484
Pohjalainen T / 1998 / The A1 allele of the human D2 dopamine receptor gene predicts low D2 receptor availability in healthy volunteers / Mol Psychiatry 3:256~260
JÖnsson EG / 1999 / Polymorphisms in the dopamine D2 receptor gene and their relationships to striatal dopamine receptor density of healthy volunteers / Mol Psychiatry 4:290~296
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