지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objectives The aim of this study is to explore the association among DRD4 polymorphism, temperament and alcohol drinking behavior of Koreans in their early adulthood. Method Participants were 172 healthy Korean adults (mean age $28.1{\pm}0.8$). Their temperament was assessed with the Temperament and Character Inventory (TCI) and their alcohol drinking behavior were evaluated with a self-reported questionnaire including the CAGE and the Korean version of Alcohol Use Disorder Identification Test (AUDIT-K). DRD4 exon III 48 base pair variable number of tandem repeats (VNTR) was genotyped by PCR. Results No significant association was found between DRD4 polymorphism and TCI temperament dimension (novelty seeking, harm avoidance, reward dependence, and persistence) as well as alcohol drinking behavior scales. However, novelty seeking was significantly associated with alcohol drinking behavior. The higher level of novelty seeking was associated with the higher severity index of drinking (B = -0.225, p < 0.001) and problematic alcohol use on the CAGE and AUDIT-K [Odds Ratio (OR) = 1.111, 95% Confidence Interval (CI) 1.021-1.209, p = 0.015, OR = 1.087, 95% CI 1.009-1.170, p = 0.028]. Conclusion In our study, while there is no significant association of DRD4 polymorphism with temperament and alcohol drinking behavior, novelty seeking affects problematic alcohol use. Results suggest that novelty seeking may play an important role in problematic alcohol use in young Korean adults.
목차
등록된 정보가 없습니다.
참고문헌 (41)
참고문헌 신청
Tyndale RF / 2003 / Genetics of alcohol and tobacco use in humans / Ann Med 35:94~121
Noble EP / 1998 / D2 and D4 dopamine receptor polymorphisms and personality / Am J Med Genet 81:257~267
Cox WM / 1988 / A motivational model of alcohol use / J Abnorm Psychol 97:168~180
Lee JI / 2005 / Acute alcohol responses and personality traits by aldehyde dehydrogenase 2 genotype variances in patients with alcohol dependence / Korean J Biol Psychiatry 12:196~206
Cooper ML / 1995 / Drinking to regulate positive and negative emotions: a motivational model of alcohol use / J Pers Soc Psychol 69:990~1005
Noble EP / 1998 / D2 and D4 dopamine receptor polymorphisms and personality / Am J Med Genet 81:257~267
Cox WM / 1988 / A motivational model of alcohol use / J Abnorm Psychol 97:168~180
Lee JI / 2005 / Acute alcohol responses and personality traits by aldehyde dehydrogenase 2 genotype variances in patients with alcohol dependence / Korean J Biol Psychiatry 12:196~206
Cooper ML / 1995 / Drinking to regulate positive and negative emotions: a motivational model of alcohol use / J Pers Soc Psychol 69:990~1005
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