지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Stress, a risk factor of major depression induces cytokine mediated inflammation and decreased neurogenesis. In patients with major depression, significant increases of pro-inflammatory cytokines have been consistently reported. The pro-inflammatory cytokines can stimulate the hypothalamic-pituitary-adrenal (HPA) axis to release glucocorticoids. In the brain, microglia and play a role of immune activation in response to stress. Increased pro-inflammatory cytokine play a role in restricting neurogenesis in the brain. Although neurogenesis may not be essential for the development of depression, it may be required for clinically effective antidepressant treatment. Hence, stimulation of neurogenesis is regarded as a promising strategy for new antidepressant targets. This review introduces changes in neurotransmitter, cytokine and neurogenesis in major depression and explores the possible relationship between pro-inflammatory cytokines and neurogenesis related to stress in major depression.
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참고문헌 (84)
참고문헌 신청
Heim C / 2001 / The role of childhood trauma in the neurobiology of mood and anxiety disorders: preclinical and clinical studies / Biol Psychiatry 49:1023~1039
Heim C / 1999 / The impact of early adverse experiences on brain systems involved in the pathophysiology of anxiety and affective disorders / Biol Psychiatry 46:1509~1522
Schildkraut JJ / 1965 / The catecholamine hypothesis of affective disorders: a review of supporting evidence / Am J Psychiatry 122:509~522
Duman RS / 1997 / A molecular and cellular theory of depression / Arch Gen Psychiatry 54:597~606
Maes M / 2008 / The cytokine hypothesis of depression: inflammation, oxidative& nitrosative stress (IO & NS) and leaky gut as new targets foradjunctive treatments in depression / Neuro Endocrinol Lett 29:287~291
Heim C / 1999 / The impact of early adverse experiences on brain systems involved in the pathophysiology of anxiety and affective disorders / Biol Psychiatry 46:1509~1522
Schildkraut JJ / 1965 / The catecholamine hypothesis of affective disorders: a review of supporting evidence / Am J Psychiatry 122:509~522
Duman RS / 1997 / A molecular and cellular theory of depression / Arch Gen Psychiatry 54:597~606
Maes M / 2008 / The cytokine hypothesis of depression: inflammation, oxidative& nitrosative stress (IO & NS) and leaky gut as new targets foradjunctive treatments in depression / Neuro Endocrinol Lett 29:287~291
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