지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Depression and executive dysfunction are common neuropsychiatric sequelae of stroke. Patients with stroke are more predisposed to depression and executive dysfunction compared to patients with similar degree of physical disability. Both depression and executive dysfunction are also associated with poor prognosis such as high mortality and delayed recovery after stroke. Complex neurobiological and anatomical mechanisms are associated with the development of depression and executive dysfunction after stroke. Activation of pro-inflammatory cytokines is thought to be associated with onset of depression, whereas injuries in frontal-subcortical circuit are thought to be a link between depression and executive dysfunction. Early detection of depressive symptoms and both pharmacological and non-pharmacological treatment would be helpful. In this review paper, the authors investigated 1) biological and neuroanatomical substrate for poststroke depression and executive dysfunction, 2) the relationship and common etiopathology for poststroke depression and executive dysfunction, and 3) pharmacological and non-pharmacological treatment for poststroke depression. The contents of the paper are as follows : the prevalence, clinical manifestation, and biological etiology for poststroke depression, neuroanatomical abnormalities as a common etiological factor for depression and executive dysfunction, pharmacotherapy and non-pharmacological approach.
목차
등록된 정보가 없습니다.
참고문헌 (67)
참고문헌 신청
Lenzi GL / 2008 / Post-stroke depression / Rev Neurol (Paris) 164:837~840
Maes M / 2009 / The inflammatory & neurodegenerative (I & ND) hypothesis of depression: leads for future research and new drug developments in depression / Metab Brain Dis 24:27~53
Di Carlo A / 2000 / Frequency of stroke in Europe: A collaborative study of population-based cohorts. ILSA Working Group and the Neurologic Diseases in the Elderly Research Group. Italian Longitudinal Study on Aging / Neurology 54(11 Suppl 5):S28~S33
Maes M / 2009 / Inflammatory and oxidative and nitrosative stress pathways underpinning chronic fatigue, somatization and psychosomatic symptoms / Curr Opin Psychiatry 22:75~83
Aben I / 2003 / A comparative study into the one year cumulative incidence of depression after stroke and myocardial infarction / J Neurol Neurosurg Psychiatry 74:581~585
Maes M / 2009 / The inflammatory & neurodegenerative (I & ND) hypothesis of depression: leads for future research and new drug developments in depression / Metab Brain Dis 24:27~53
Di Carlo A / 2000 / Frequency of stroke in Europe: A collaborative study of population-based cohorts. ILSA Working Group and the Neurologic Diseases in the Elderly Research Group. Italian Longitudinal Study on Aging / Neurology 54(11 Suppl 5):S28~S33
Maes M / 2009 / Inflammatory and oxidative and nitrosative stress pathways underpinning chronic fatigue, somatization and psychosomatic symptoms / Curr Opin Psychiatry 22:75~83
Aben I / 2003 / A comparative study into the one year cumulative incidence of depression after stroke and myocardial infarction / J Neurol Neurosurg Psychiatry 74:581~585
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