지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Objectives : Proinflammatory process has been implicated as an underlying mechanism of bipolar disorder and schizophrenia. Previous studies have suggested a possible role of lymphotoxin alpha (LTA) gene in the development of schizophrenia and have prompted further investigation in bipolar patients. Association of the LTA +252A/G polymorphism with susceptibility to bipolar I disorder itself as well as with vulnerability among a subset of psychotic bipolar patients were tested. Methods : DNA extraction was done by a standard method and genotyping was carried out by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method in 114 Korean patients with bipolar I disorder and 202 healthy controls. SPSS v18.0 was used for statistical analysis. Comparisons of the genotype and allele distributions in LTA +252A/G polymorphism were made using a chi-square test. The genotype and allele associations were also evaluated using odds ratio (OR) and 95% confidence interval (CI). Statistical significance was accepted when p was < 0.05. Results : No significant association was found between the LTA +252A/G polymorphism and bipolar disorder. However, LTA +252G allele was present with significantly higher frequency among bipolar patients with psychotic features compared to those without (${\chi}^2$ = 4.69, p = 0.034, OR = 2.495, 95% CI = 1.069-5.827). Conclusion : The results suggest that the allele LTA +252G of the polymorphism may be associated with the psychotic subset of bipolar disorder but not with bipolar I disorder itself. Adequately powered subsequent studies should be conducted.
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참고문헌 (44)
참고문헌 신청
McGuffin P / 2003 / The heritability of bipolar affective disorder and the genetic relationship to unipolar depression / Arch Gen Psychiatry 60:497~502
Craddock N / 1999 / Genetics of bipolar disorder / J Med Genet 36:585~594
Tsai SY / 1999 / Activation of indices of cell-mediated immunity in bipolar mania / Biol Psychiatry 45:989~994
Brietzke E / 2009 / Comparison of cytokine levels in depressed, manic and euthymic patients with bipolar disorder / J Affect Disord 116:214~217
Kunz M / 2011 / Serum levels of IL-6, IL-10 and TNF-α in patients with bipolar disorder and schizophrenia: differences in pro- and anti-inflammatory balance / Rev Bras Psiquiatr 33:268~274
Craddock N / 1999 / Genetics of bipolar disorder / J Med Genet 36:585~594
Tsai SY / 1999 / Activation of indices of cell-mediated immunity in bipolar mania / Biol Psychiatry 45:989~994
Brietzke E / 2009 / Comparison of cytokine levels in depressed, manic and euthymic patients with bipolar disorder / J Affect Disord 116:214~217
Kunz M / 2011 / Serum levels of IL-6, IL-10 and TNF-α in patients with bipolar disorder and schizophrenia: differences in pro- and anti-inflammatory balance / Rev Bras Psiquiatr 33:268~274
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