Objectives: The purpose of this study was to analyze factors affecting school life adjustment of athletes in middle and high school. Methods: The data in this study came from the survey which conducted to 500 students of physical education high school athletes and elite athletes in general school from the beginning of December 2009 to the end of January 2010 in Seoul and Kyunggi. Finally 436 cases was used. The dependant variable in this study was school life adjustment. And the independent variables were socio-demographic factors, stress and depression factors, social support factors. The analysis methods were T-test, ANOVA, correlation analysis, stepwise multiple regression analysis by using SPSS Ver. 12.0. Results: First, there was a statistically significant result between school life adaptation and sex, family circumstances, life satisfaction variables Second, there was a negative correlation between social support and stress, depression. Third, there was a negative correlation between school life adjustment and some stress factors, all depression factors. Also relationship between school life adjustment and social support showed a positive correlation. Fourth, Taking a look at the impact on school life adjustment, family factors and practical environmental factors in the stress factors and the feeling of worthlessness in the depression factors appeared to influence negatively. Also teachers' support in the social support factors showed positive effects. Explanatory power of the final regression model was 25.6%. Conclusions: The first step in order to improve the school life adjustment of athletes in middle and high school is the teachers' support. Athletes in middle and high school can have capability, responsibility, initiatives through teachers' attention and affection. The effective prevention education and health education programs on stress and depression should be introduced and carried out in the health education programs actively for student athletes to be free from stress, depression.