지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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PURPOSE: This study examined the effects of exercise of diverse intensities on the expression of TNF-${\alpha}$(tumor necrosis factor-${\alpha}$) in the spinal cord in osteoarthritic rats. METHODS: Over a period of four weeks, the authors applied treadmill exercise programs of diverse intensities to Sprague-Dawley rats, to which intra-articular injection of monosodium iodoacetate(MIA, $3mg/50{\mu}l$, diluted in saline) was applied to the right knee joint to induce osteoarthritis. The four-week exercise program was not carried out with the control group(CG, n=10). Exercise programs of applicable intensities were applied to the low-intensity exercise group(LEG, n=10), moderate-intensity exercise group (MEG, n=10), and high-intensity exercise group(HEG, n=10) over the four weeks. Observations were made of expression of TNF-${\alpha}$ in the spinal cord in osteoarthritic rats using western blot analysis. RESULT: there were significant differences(p<.05) in the comparison of expression of TNF-${\alpha}$ between the four groups involved. The expression of TNF-${\alpha}$ in the spinal cord, the LEG and HEG had more elevated expression significantly than the CG(p<.05). But the MEG had reduced expression significantly than the CG(p<.05). CONCLUSION: These study results suggest that moderate-intensity exercise is effective in inhibition TNF-${\alpha}$ in the spinal cord. They also indicate that in prescribing exercise to treat osteoarthritic patients, exercise of moderate intensity is most suitable to patients' chronic pain, rather than low or high intensity.
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참고문헌 (37)
참고문헌 신청
Baek KY / 2008 / The effect of different exercise intensity on the blood pressure and inflammatory markers change in pre-hypertension leveled male
Bove SE / 2003 / Weight bearing as a measure of disease progression and efficacy of anti-inflammatory compounds in a model of monosodium iodoacetate-induced osteoarthritis / Osteoarthritis Cartilage 11(11):821~830
Byun KS / 2010 / Effect of exercise intensity on GLUT-4 expression of skeletal muscle and insulin resistance in type 1 diabetic rats
Choi JK / 2010 / Effects of high intensity exercise and DA-9601 administration on antioxidant enzyme activities and TNF-α, IL-1β mRNA expression in rats
Combe R / 2004 / The monosodium iodoacetate model of osteoarthritis: a model of chronic nociceptive pain in rats? / Neurosci Lett 370(2,3):236~240
Bove SE / 2003 / Weight bearing as a measure of disease progression and efficacy of anti-inflammatory compounds in a model of monosodium iodoacetate-induced osteoarthritis / Osteoarthritis Cartilage 11(11):821~830
Byun KS / 2010 / Effect of exercise intensity on GLUT-4 expression of skeletal muscle and insulin resistance in type 1 diabetic rats
Choi JK / 2010 / Effects of high intensity exercise and DA-9601 administration on antioxidant enzyme activities and TNF-α, IL-1β mRNA expression in rats
Combe R / 2004 / The monosodium iodoacetate model of osteoarthritis: a model of chronic nociceptive pain in rats? / Neurosci Lett 370(2,3):236~240
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