지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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PURPOSE: To identify the effects of single trial transcutaneous electrical nerve stimulation (TENS) application on chronic neuropathic pain and the repeated TENS application to development of neuropathic pain following peripheral nerve injury. METHODS: First, 20 rats were given the median nerve ligation to induce chronic neuropathic pain. After the ligation, neuropathic pain was assessed by measuring the forepaws withdrawal threshold to von Frey filaments for 3 weeks. Afterward, rats were randomly divided into TENS group and placebo-TENS group. TENS (frequency 100Hz, pulse width $200{\mu}s$) was applied to the forearm for 20 minutes. Second, 34 rats were randomly allocated into two group after median nerve ligation: TENS group and placebo-TENS group. Both interventions were applied to the forearm for 20 minutes from 1 day to 3 weeks after injury. Neuropathic pain to mechanical was measured on each rat for 3 weeks. RESULTS: Exeprimental rats showed a clear neuropathic pain-like behaviors, such as reduced forepaw withdrawal threshold to mechanical stimulation for 3 weeks, after median nerve ligation. And, TENS decreased effectively the chronic neuropathic pain originated from median nerve injury. TENS also diminished the development of neuropathic pain after nerve injury. CONCLUSION: Our animal model studying for neuropathic pain following median nerve injury may be useful to investigate peripheral neuropathic pain in human. Also, TENS may be used to mediate chronic neuropathic pain and to prevent the development of neuropathic pain following median nerve injury.
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참고문헌 (48)
참고문헌 신청
Ainsworth L / 2006 / Transcutaneous electrical nerve stimulation (TENS) reduces chronic hyperalgesia induced by muscle inflammation / Pain 120(1,2):182~187
Armand J / 1982 / The origin, course and terminations of corticospinal fibers in various mammals / Prog Brain Res 57:329~360
Bennett GJ / 1991 / The role of the sympathetic nervous system in painful peripheral neuropathy / Pain 45(3):221~223
Bennett GJ / 1988 / A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man / Pain 33(1):87~107
Bridges D / 2001 / Mechanisms of neuropathic pain / Br J Anaesth 87(1):12~26
Armand J / 1982 / The origin, course and terminations of corticospinal fibers in various mammals / Prog Brain Res 57:329~360
Bennett GJ / 1991 / The role of the sympathetic nervous system in painful peripheral neuropathy / Pain 45(3):221~223
Bennett GJ / 1988 / A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man / Pain 33(1):87~107
Bridges D / 2001 / Mechanisms of neuropathic pain / Br J Anaesth 87(1):12~26
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