생맥산 및 평위산 추출물의 위장관 운동 조절 효능에 관한 연구

이민철; 박진령; 심지환; 안태석; 김병주

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자료유형: 학술저널

저자정보: 이민철 (부산대학교 한의학전문대학원 양생기능의학부) 박진령 (부산대학교 한의학전문대학원 양생기능의학부) 심지환 (부산대학교 한의학전문대학원 양생기능의학부) 안태석 (부산대학교 한의학전문대학원 양생기능의학부) 김병주 (부산대학교 한의학전문대학원 양생기능의학부)

저널정보: 한방비만학회 한방비만학회지 대한한방비만학회지 제15권 제2호

발행연도: 2015.1

수록면: 68 - 74 (7page)

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연구배경

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연구방법

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연구결과

초록· 키워드

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Objectives: The purpose of this study was to investigate the effects of Shengmai-san and Pyungwi-san, a herbal product used in traditional Chinese medicine, on gastrointestinal (GI) motility in mice. Methods: The in vivo effects of Shengmai-san and Pyungwi-san on GI motility were investigated by measuring the intestinal transit rates (ITRs) using Evans blue in normal mice and in mice with experimentally induced GI motility dysfunction (GMD). GMD was induced by injecting acetic acid or streptozotocin intraperitoneally. Results: In normal Institute of Cancer Research mice, ITRs were significantly and dose-dependently increased by Shengmaisan (0.01~1 g/kg) and Pyungwi-san (0.01~1 g/kg). The ITRs of acetic acid induced peritoneal irritation model and streptozotocin-induced diabetic model mice were significantly reduced compared to normal mice, and these reductions were significantly and dose-dependently inhibited by Shengmai-san (0.01~1 g/kg) and Pyungwi-san (0.01~1 g/kg). Conclusions: These results suggest that both Shengmai-san and Pyungwi-san are a good candidate for the development of a prokinetic agent that may prevent or alleviate GMD.

#Gastrointestinal disease #Shengmai-san #Pyungwi-san #Gastrointestinal motility #Gastrointestinal tract #Intestinal transit rate

참고문헌 (38)

참고문헌 신청

Cheng JT / 2000 / Review: drug therapy in Chinese traditional medicine / J Clin Pharmacol 40(5):445~450

Xu N / 2011 / HPLC/MS/MS for quantification of two types of neurotransmitters in rat brain and application: myocardial ischemia and protection of Sheng-Mai-San / J Pharm Biomed Anal 55(1):101~108

Nishida H / 2007 / Amyloid-β-induced cytotoxicity of PC- 12 cell was attenuated by Shengmai-san through redox regulation and outgrowth induction / J Pharmacol Sci 104(1):73~81

Wang NL / 2005 / Shengmai san, a Chinese herbal medicine protects against rat heat stroke by reducing inflammatory cytokines and nitric oxide formation / J Pharmacol Sci 98(1):1~7

Riedlinger JE / 2001 / Ping wei san, a Chinese medicine for gastrointestinal disorders / Ann Pharmacother 35(2):228~235

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