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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Objectives : In this study, we investigated the effect of modified-Okbyungpoongsan (mOP) on mast cell-mediated allergic response in basophilic leukemia cell line, RBL-2H3 mast cells. Methods : Cells were stimulated with anti-DNP-IgE after the treatment of DNP-HSA (AI/D), and then incubated with different concentrations of mOP (0.1, 0.2, 0.5 and 1 mg/$m{\ell}$) in RBL-2H3 cells. Cell toxicity was determined by WST-1 assay. The degranulation of mast cells was observed by microscope with toluidine blue staining and also the levels of beta-hexosaminidase, histamine and TNF-alpha were measured in culture supernatants by enzyme-linked immunosorbant assay. Results : mOP inhibited anti-DNP-IgE-imduced degranulation of mast cells in RBL-2H3 cells. mOP also significantly decreased the levels of histamine and inflammatory cytokine, TNF-alpha in RBL-2H3 cells, but slightly decreased the level of beta-hexosaminidase. Conclusions : These results indicate that mOP, an oriental prescription could be inhibit the allergic response through suppressing the mast cell activation.
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참고문헌 (29)
참고문헌 신청
Korean Journal of Asthma / 2002 / Asthma and Allergy disease / koonja publisher :431~433
Seoul National University College of Medicine / 1987 / Immunology / Seoul National University publishe :188~197
Min YK / 2002 / Otorhinolaryngology for primary care / iljokac :60~62
Poole JA / 2005 / The role of immunoglobulin E and immune inflammation： implications in allergic rhinitis / Curr Allergy Asthma Rep 5(3):252~258
Borish L / 2003 / Allergic rhinitis： systemic inflammation and implications for management / J Allergy Clin Immunol 112(6):1021~1031
Seoul National University College of Medicine / 1987 / Immunology / Seoul National University publishe :188~197
Min YK / 2002 / Otorhinolaryngology for primary care / iljokac :60~62
Poole JA / 2005 / The role of immunoglobulin E and immune inflammation： implications in allergic rhinitis / Curr Allergy Asthma Rep 5(3):252~258
Borish L / 2003 / Allergic rhinitis： systemic inflammation and implications for management / J Allergy Clin Immunol 112(6):1021~1031
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