지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 33 - 44 (12page)
이용수
초록· 키워드
오류제보하기
Objectives : There is a pressing need to determine the clinical and scientific validity of herbal therapies for animal model with atopic dermatitis since some differences in systemic cytokine polarization between in animal model and in patients with atopic dermatitis has been reported. New studies for tang, medicinal herb itself or effective ingradients of medicinal herb showing anti-atopic dermatitis effectiveness are reviewed in terms of cytokine regulation. Methods : Those herbal therapies used to treat atopic dermatitis in animal model were introduced and the expression pattern of cytokine and the activity of mast cell were compared in both animal model and patients with atopic dermatitis. Results : In case of atopic dermatitis in human, there is a biphasic pattern of cytokine expression in atopic dermatitis, with acute skin inflammation associated with a predominance of IL-4 and IL-13 expression from Th2 cells, and chronic inflammation associated with increased IL-5 from Th2-cells and IFN-${\gamma}$ from Th1-cells. However, a pattern of cytokine expression in animal model with atopic dermatitis is not matched well to the biphasic pattern of cytokine expression in patients with atopic dermatitis. In addition, a kind of cytokine is different by animal model with atopic dermatitis. These differences would make herbal medicines, showing their effectiveness on atopic dermatitis, difficult to apply to patients with atopic dermatitis. Conclusion : The pattern of local cytokine expression plays an important role in modulating tissue inflammation, and in atopic dermatitis this pattern depends on the acuity or duration of the skin lesion. Thus, in order to develop medicinal herb itself or effective ingradients of medicinal herb showing anti-atopic dermatitis effectiveness, biphasic pattern of cytokine expression should be considered in animal model with atopic dermatitis.
목차
등록된 정보가 없습니다.
참고문헌 (44)
참고문헌 신청
Dorlands Medical Dictionary : "Atopy"
Mosby's Medical Dictionary : "Atopy"
Wikipedia : "Atopy"
Novak N. / 2003 / Immune mechanisms leading to atopic dermatitis / J Allergy Clin Immunol 112(6):S128~S139
Larsen FS. / 1996 / The occurrence of atopic dermatitis in North Europe : an international questionnaire study / J Am Acad Dermatol 34:760~764
Mosby's Medical Dictionary : "Atopy"
Wikipedia : "Atopy"
Novak N. / 2003 / Immune mechanisms leading to atopic dermatitis / J Allergy Clin Immunol 112(6):S128~S139
Larsen FS. / 1996 / The occurrence of atopic dermatitis in North Europe : an international questionnaire study / J Am Acad Dermatol 34:760~764
이 논문의 저자 정보
최근 본 자료
댓글(0)
0