지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 경희한의학연구센터 Oriental pharmacy and experimental medicine Oriental pharmacy and experimental medicine 제11권 제4호
- 발행연도
- 2011.1
- 수록면
- 293 - 298 (6page)
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초록· 키워드
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Over production of gastric acid in response to various stimuli is responsible for peptic ulceration in majority of patients. Calcium plays an important role in the release of various stimulant mediators. The aerial part of $Carthamus$ $tinctorius$ L. are reported to have calcium channel blocking activity. This study was designed to find out the effects of extract on the volume and acidity, free and total, of $Carbachol$ induced gastric secretion and to compare the results with that of $Cimetidine$ $and$ $Verapamil$ on the same parameters. The animals were kept on fasting for 48 h after which the pylorus of each animal was ligated. The extract was administered 200 and 400 mg/kg of body weight, $Cimetidine$ 2.5 mg/kg and $Carbachol$ 600 ${\mu}g$/kg and $Verapamil$ 10 mg/kg body weight, intraperitoneally, in pylorus ligated rats. It was found that the extract reduced the volume, free and total acidity of gastric secretion, which were statistically highly significant when compared with $Carbachol$ ($P$ <0.001). $Cimetidine$ also had the same effects. When the difference of mean values, brought about by extract, was compared with those of $Cimetidine$, it was found that these differences in the volume and free acidity were significant indicating that $Cimetidine$ is more effective than the extract. The extract can, however, be used effectively in the treatment of peptic ulcer. Although, the extract reduced gastric acidity significantly, but is less effective than $Cimetidine$.
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