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Flavonoids show diverse bioactivities, such as anti-oxidant, anti-cancer, anti-allergic, anti-inflammatory, and anti-viral. Quercetin is one of the flavonoids present in a wide range of plants, especially onions and consumed all over the world. Recently, it is known that quercetin induces mitochondrial biogenesis in vivo and in vitro. However, detail mechanism of these actions remains unknown. We investigated quercetin's effects on mitochondrial biogenesis in HepG2 cells, and determined the mechanisms involved. We found that quercetin treatment induced the expression of mitochondrial biogenesis activators, $PGC-1{\alpha}$, NRF-1, TFAM, and mitochondrial proteins, cytochorome c and complex IV (COXIV). Moreover, amount of mitochondrial DNA was also increased by quercetin. Quercetin has been known to induce heme oxygenase (HO)-1 in several types of cells. Here, we found quercetin induces HO-1, and inhibition of HO-1 or CO, which is product of HO-1, decreased quercetin-induced mitochondrial biogenesis such as induction of $PGC-1{\alpha}$, NRF-1, TFAM, cytochorome c, COXIV, and mitochondrial DNA. These findings imply that quercetin can increase mitochondrial biogenesis via HO-1/CO system. High glucose results in dysfunction of mitochondria biogenesis. In the present study, 25 mM glucose decreased mitochondrial biogenesis and this damage was restored by quercetin. Conversely, inhibition of HO-1 or CO inhibited quercetin-induced mitochondrial biogenesis rescue. These results suggest that quercetin enhances mitochondrial biogenesis via HO-1/CO system and hence, can rescue mitochondria from damage by high glucose.
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Autophagy Inhibition Promotes Quercetin Induced Apoptosis in MG-63 Human Osteosarcoma cells
International Journal of Oral Biology
2015 .01
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Differential Effects of Quercetin and Quercetin Glycosides on Human α7 Nicotinic Acetylcholine Receptor-Mediated Ion Currents
Biomolecules & Therapeutics(구 응용약물학회지)
2016 .01
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Preventive and Therapeutic Effects of Quercetin on Experimental Radiation Induced Lung Injury in Mice
Asian Pacific journal of cancer prevention : APJCP
2015 .01
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Quercetin induces cell death by caspase-dependent and p38 MAPK pathway in EGFR mutant lung cancer cells
고신대학교 의과대학 학술지
2016 .01
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Quercetin induces apoptosis and cell cycle arrest in triple-negative breast cancer cells through modulation of Foxo3a activity
The Korean Journal of Physiology & Pharmacology
2017 .03
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Rg3 Improves Mitochondrial Function and the Expression of Key Genes Involved in Mitochondrial Biogenesis in C2C12 Myotubes
Diabetes and Metabolism Journal
2016 .01
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Regulating Mitochondrial Biogenesis: from Herbal Remedies to Phytomedicine for Cancer Prevention
Asian Pacific journal of cancer prevention : APJCP
2015 .01
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Quercetin Directly Interacts with Vitamin D Receptor (VDR): Structural Implication of VDR Activation by Quercetin
Biomolecules & Therapeutics(구 응용약물학회지)
2016 .01
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Quercetin Down-regulates IL-6/STAT-3 Signals to Induce Mitochondrial-mediated Apoptosis in a Non-small-cell Lung-cancer Cell Line, A549
Journal of Pharmacopuncture
2015 .01
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Targeting Mitochondrial Dysfunction for the Prevention and Treatment of Metabolic Disease by Bioactive Food Components
지질·동맥경화학회지
2024 .09
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Far-infrared rays enhance mitochondrial biogenesis and GLUT3 expression under low glucose conditions in rat skeletal muscle cells
The Korean Journal of Physiology & Pharmacology
2021 .01
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Role of the mitochondrial stress response in human cancer progression
한국실험동물학회 학술발표대회 논문집
2021 .07
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Effect of proton beam irradiation on cytotoxicity and anti-inflammatory activity of quercetin
한국실험동물학회 학술발표대회 논문집
2016 .08
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Quercetin attenuates neuronal cells damage in a middle cerebral artery occlusion animal model and HT-22 cells
한국실험동물학회 학술발표대회 논문집
2018 .07
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Quercetin reduces the injury-induced reduction of γ-enolase expression in a middle cerebral artery occlusion animal model
한국실험동물학회 학술발표대회 논문집
2018 .07
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Quercetin protects neuronal cells against focal cerebral ischemia and glutamate-induced damage via inhibition of apoptotic pathway
한국실험동물학회 학술발표대회 논문집
2017 .08
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Modulation of the Expression of the GABAA Receptor β1 and β3 Subunits by Pretreatment with Quercetin in the KA Model of Epilepsy in Mice
Journal of Pharmacopuncture
2016 .01
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Quercetin Upregulates Uncoupling Protein 1 in White/Brown Adipose Tissues through Sympathetic Stimulation
Journal of Obesity & Metabolic Syndrome
2018 .01
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The effects of Korean Red Ginseng on heme oxygenase-1 with a focus on mitochondrial function in pathophysiologic conditions
Journal of Ginseng Research
2023 .09
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Comparative Effects of Dietary Quercetin and Rutin in Rats Fed with the Lieber-DeCarli Ethanol Diet
Natural Product Sciences
2017 .09
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