지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 91 - 99 (9page)
이용수
초록· 키워드
오류제보하기
Objectives The loss of maternal care during early postnatal period may increase development of mood-related disorders, such as depression, anxiety, and personality disorders. In this study, the effect of acupuncture on depression in relation with cell proliferation in the hippocampal gyrus dentatus was investigated using maternal-separated rat pups. Methods On the postnatal 14th day, rat pups from six dams were grouped into following groups: maternal care group, maternal separation group, maternal separation and non-acupoint-acupunctured group, maternal separation and Zusanli-acupunctured group, and maternal separation and fluoxetine-treated group. Acupuncture was performed from postnatal 28th day to postnatal 37th day. The rat pups that belong in the maternal separation and fluoxetine-treated group were injected subcutaneously with 5 mg/kg fluoxetine hydrochloride once a day for the same period of time. To evaluate activity of the rat pups, open field test was performed. Immunohistochemistry for serotonin (5-hydroxytryptamine, 5-HT) and tryptophan hydroxylase (TPH) in the dorsal raphe and for 5-bromo-2'-deoxyuridine (BrdU) in the hippocampal gyrus dentatus was conducted. Results The present results reveal that the activity was decreased by maternal separation. In contrast, acupuncture at Zusanli overcame maternal separation-induced hypoactivity. Maternal separation suppressed TPH expression and 5-HT synthesis in the dorsal raphe and decreased cell proliferation in the hippocampal gyrus dentatus of rat pups. In contrast, acupuncture at Zusanli alleviated maternal separation-induced decrease of 5-HT synthesisand TPH expression. Conclusions The present results demonstrate that acupuncture at Zusanli ameliorated depressive state through increasing cell proliferation and enhancing 5-HT synthesis.
목차
등록된 정보가 없습니다.
참고문헌 (29)
참고문헌 신청
Aisa B / 2009 / Effects of neonatal stress on markers of synaptic plasticity in the hippocampus : implications for spatial memory / Hippocampus 19(12):1222~1231
Marais L / 2008 / Maternal separation of rat pups increases the risk of developing depressive-like behavior after subsequent chronic stress by altering corticosterone and neurotrophin levels in the hippocampus / Neurosci Res 61(1):106~112
Sung YH / 2010 / Depression-like state in maternal rats induced by repeated separation of pups is accompanied by a decrease of cell proliferation and an increase of apoptosis in the hippocampus / Neurosci Lett 470(1):86~90
Park HJ / 2002 / Acupuncture enhances cell proliferation in dentate gyrus of maternally-separated rats / Neurosci Lett 319(3):153~156
Christiansen L / 2007 / Candidate gene polymorphisms in the serotonergic pathway : influence on depression symptomatology in an elderly population / Biol Psychiatry 61(2):223~230
Marais L / 2008 / Maternal separation of rat pups increases the risk of developing depressive-like behavior after subsequent chronic stress by altering corticosterone and neurotrophin levels in the hippocampus / Neurosci Res 61(1):106~112
Sung YH / 2010 / Depression-like state in maternal rats induced by repeated separation of pups is accompanied by a decrease of cell proliferation and an increase of apoptosis in the hippocampus / Neurosci Lett 470(1):86~90
Park HJ / 2002 / Acupuncture enhances cell proliferation in dentate gyrus of maternally-separated rats / Neurosci Lett 319(3):153~156
Christiansen L / 2007 / Candidate gene polymorphisms in the serotonergic pathway : influence on depression symptomatology in an elderly population / Biol Psychiatry 61(2):223~230
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