산사의 장내 미생물 조절을 통한 항비만 효과

김민지; 최유라; 신나래; 이명종; 김호준

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자료유형: 학술저널

저자정보: 김민지 (동국대학교 한의과대학 한방재활의학과교실) 최유라 (동국대학교 한의과대학 한방재활의학과교실) 신나래 (동국대학교 한의과대학 한방재활의학과교실) 이명종 (동국대학교 한의과대학 한방재활의학과교실) 김호준 (동국대학교 한의과대학 한방재활의학과교실)

저널정보: 한방재활의학과학회 한방재활의학과학회지 한방재활의학과학회지 제29권 제4호

발행연도: 2019.1

수록면: 15 - 27 (13page)

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연구배경

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연구방법

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연구결과

초록· 키워드

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Objectives This study was performed to evaluate anti-obesity effects of Crataegus pinnatifida (CP) on high-fat-diet induced obese mice. Methods The experimental animals were divided into four groups: normal diet (NOR) group, high fat diet (HFD) group, HFD+Xenical (XEN) group, and HFD+CP (CP) group. NOR group was fed a normal diet and the other three groups were fed high fat diet during the experiment. After the first two weeks of diet, XEN group and CP group were administered with XEN or CP for seven weeks, respectively. After that, we measured body weight, liver weight, fat weight, food intake, and serum concentrations of lipids and liver enzymes. Also the liver, intestine, fat tissue was removed to estimate the obesity-related mRNA expressions and the stool sample was collected to analyze the gut microbiota. Results We found that body weight, fat weight, and triglyceride level were decreased significantly in CP group compared to HFD group. Also CP significantly suppressed gene expressions associated with lipogenesis and inflammation, and increased gene expressions of browning of white adipose tissue and mitochondrial biogenesis. Moreover, it shifted the microbial diversity closer to that of NOR group and increased Firmicutes/Bacteriodetes ratio. Conclusions These results suggest that CP decrease body weight, fat weight and serum triglyceride. Also it inhibit inflammation and adipogenesis, altering gut microbial diversity and abundance. In conclusion, CP could be used as a therapeutic drug for obesity via gut microbiota modulation.

#Crataegus #Microbiota #Obesity

참고문헌 (36)

참고문헌 신청

World Health Organization / Obesity and overweight / WHO Fact sheet

서미혜 / 2018 / Prevalence of Obesity and Incidence of Obesity-Related Comorbidities in Koreans Based on National Health Insurance Service Health Checkup Data 2006–2015 / Journal of Obesity & Metabolic Syndrome 27(1):46~52

Everett E / 2003 / The effect of body mass index on clinical/pathologic features, surgical morbidity, and outcome in patients with endometrial cancer / Gynecol Oncol 90(1):150~157

v on Gruenigen VE / 2008 / Feasibility and effectiveness of a lifestyle intervention program in obese endometrial cancer patients : a randomized trial / Gynecol Oncol 109(1):19~26

서미혜 / 2019 / 2018 Korean Society for the Study of Obesity Guideline for the Management of Obesity in Korea / Journal of Obesity & Metabolic Syndrome 28(1):40~45

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