Diagnostic and Clinical Significance of KIT(CD117) Expression in Thymic Epithelial Tumors in China

Song, Nan; Chen, Gang; Zhang, Peng; Liu, Ming; He, Wen-Xin; Jiang, Ge-Ning

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자료유형: 학술저널

저자정보: Song, Nan (Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine) Chen, Gang (Department of Pathology, Shanghai Pulmonary Hospital, Tongji University School of Medicine) Zhang, Peng (Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine) Liu, Ming (Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine) He, Wen-Xin (Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine) Jiang, Ge-Ning (Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제13권 제6호

발행연도: 2012.1

수록면: 2,745 - 2,748 (4page)

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Aims: To study KIT (CD117) expression in thymic epithelial tumors in China, and investigate diagnostic and clinical significance. Material and Methods: Thymic epithelial tumors (TETs) from 102 patients (3 type A, 29 type AB, 5 type B1, 22 type B2, 29 typeB3 and 16 thymic carcinomas) were examined. Immunohistochemical staining with an antic-kit monoclonal antibody was performed on a tissue microarray. Relationships between KIT positive expression and the TET clinical characteristics (WHO histologic classification and Masaoka stage system) were analysed. Results: The KIT positive expression rate was significantly higher in thymic carcinoma (60%, 9/16) than in thymoma (8%, 7/86), a strong correlation being found with the WHO classification, but not the Masaoka tumor stage. The overall survival for patients with KIT positive lesions was significantly worse. Conclusions: KIT is a good molecule marker to differentially diagnose thymic carcinoma from thymoma, while also serving as a predictor of prognosis for TETs. Further research into KIT mutations in Chinese TETs should be conducted to assess the efficacy of targeted therapy.

#Thymoma #thymic carcinoma #thymic epithelial tumors #KIT

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Song, Nan

소속기관 Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine