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논문 기본 정보

자료유형
학술저널
저자정보
Cheng, Da-Qing (Department of General Surgery, Huashan Hospital, Fudan University) Gu, Xiao-Dong (Department of General Surgery, Huashan Hospital, Fudan University) Li, Zhen-Yang (Department of General Surgery, Huashan Hospital, Fudan University) Xiang, Jian-Bin (Department of General Surgery, Huashan Hospital, Fudan University) Chen, Zong-You (Department of General Surgery, Huashan Hospital, Fudan University)
저널정보
아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제9호
발행연도
2014.1
수록면
3,895 - 3,899 (5page)

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C4.4A, a metastasis-associated gene, encodes a glycolipid-anchored membrane protein which is overexpressed in several human malignancies. However, there are few data available on C4.4A expression and its relationship with progression in gastric cancer. Our study was designed to explore the expression of C4.4A in gastric cancer and to correlate it with clinical outcome. C4.4A expression was studied by quantitative real-time RT-PCR and immunohistochemistry for assessment of correlations with clinicopathological factors. C4.4A mRNA expression was significantly up-regulated in gastric cancer as compared with noncancerous tissue (p<0.05)., being observed in 107 (88.4%) of the 121 gastric cancer cases by immunohistochemistry. We found that the expression of C4.4A mRNA was correlated with size of the tumor, depth of invasion, lymph node metastasis, distant metastasis and TNM stage. Moreover, patients with overexpression of C4.4A has a significantly worse survival (p<0.05). Further multivariable analysis indicated that the expression of C4.4A was an independent prognostic indicator for gastric cancer (p<0.05). In conclusion, overexpression of C4.4A correlates with metastatic potential of gastric cancer and C4.4A could be a novel independent prognostic marker for predicting outcome.

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