Current Evidence on the Relationship Between Two Polymorphisms in the NBS1 Gene and Breast Cancer Risk: a Meta-analysis

Zhang, Zhi-Hua; Yang, Lin-Sheng; Huang, Fen; Hao, Jia-Hu; Su, Pu-Yu; Sun, Ye-Huan

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저자정보: Zhang, Zhi-Hua (Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University) Yang, Lin-Sheng (Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University) Huang, Fen (Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University) Hao, Jia-Hu (Department of Maternal and Child Health, School of Public Health, Anhui Medical University) Su, Pu-Yu (Department of Maternal and Child Health, School of Public Health, Anhui Medical University) Sun, Ye-Huan (Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제13권 제11호

발행연도: 2012.1

수록면: 5,375 - 5,379 (5page)

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Introduction: Published studies on the association between Nijmegen breakage syndrome 1(NBS1) gene polymorphisms and breast cancer risk have been inconclusive, and a meta-analysis was therefore performed for clarification. Methods: Eligible articles were identified by a search of MEDLINE and EMBASE bibliographic databases for the period up to March 2012. The presence of between-study heterogeneity was investigated using the chi-square-based Cochran's Q statistic test. When there was statistical heterogeneity, the random effects model was chosen; otherwise, fixed effects estimates were reported as an alternative approach. Results: A total of 11 eligible articles (14 case-control studies) were identified, nine case-control studies were for the 657del5 mutation (7,534 breast cancer cases, 14,034 controls) and five case-control studies were for the I171V mutation (3,273 breast cancer cases, 4,004 controls). Our analysis results indicated that the 657del5 mutation was associated with breast cancer risk (carriers vs. non-carriers: pooled OR =2.63, 95% CI: 1.76-3.93), whereas the I171V mutation was not (carriers vs. non-carriers: pooled OR =1.52, 95% CI: 0.70-3.28). Conclusion: The present meta-analysis suggests that the 657del5 gene mutation in the NBS1 gene plays a role in breast cancer risk, while the I171V mutation does not exert a significant influence.

#NBS1 gene #657del5 mutation #I171V mutation #polymorphism #cancer risk #breast cancer #meta-analysis

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Zhang, Zhi-Hua

소속기관 Department of Epidemiology and Biostatistics, School of Public Health of Anhui Medical University