Survival and Prognostic Factors for Hepatocellular Carcinoma: an Egyptian Multidisciplinary Clinic Experience

Abdelaziz, Ashraf Omar; Elbaz, Tamer Mahmoud; Shousha, Hend Ibrahim; Ibrahim, Mostafa Mohamed; El-Shazli, Mostafa Abdel Rahman; Abdelmaksoud, Ahmed Hosni; Aziz, Omar Abdel; Zaki, Hisham Atef; Elattar, Inas Anwar; Nabeel, Mohamed Mahmoud

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저자정보: Abdelaziz, Ashraf Omar (Department Endemic Hepatogastroenterology, National Cancer Institute, Cairo University) Elbaz, Tamer Mahmoud (Department Endemic Hepatogastroenterology, National Cancer Institute, Cairo University) Shousha, Hend Ibrahim (Department Endemic Hepatogastroenterology, National Cancer Institute, Cairo University) Ibrahim, Mostafa Mohamed (Department Endemic Hepatogastroenterology, National Cancer Institute, Cairo University) El-Shazli, Mostafa Abdel Rahman (Department General Surgery, National Cancer Institute, Cairo University) Abdelmaksoud, Ahmed Hosni (Department Diagnostic and Interventional Radiology, National Cancer Institute, Cairo University) Aziz, Omar Abdel (Department Diagnostic and Interventional Radiology, National Cancer Institute, Cairo University) Zaki, Hisham Atef (Department Clinical Oncology, National Cancer Institute, Cairo University) Elattar, Inas Anwar (Department Biostatistics and Cancer Epidemiology, National Cancer Institute, Cairo University) Nabeel, Mohamed Mahmoud (Department Endemic Hepatogastroenterology, National Cancer Institute, Cairo University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제9호

발행연도: 2014.1

수록면: 3,915 - 3,920 (6page)

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Background: Hepatocellular carcinoma (HCC) is a dismal tumor with a high incidence, prevalence and poor prognosis and survival. Management of HCC necessitates multidisciplinary clinics due to the wide heterogeneity in its presentation, different therapeutic options, variable biologic behavior and background presence of chronic liver disease. We studied the different prognostic factors that affected survival of our patients to improve future HCC management and patient survival. Materials and Methods: This study is performed in a specialized multidisciplinary clinic for HCC in Kasr El Eini Hospital, Cairo University, Egypt. We retrospectively analyzed the different patient and tumor characteristics and the primary mode of management applied to our patients. Further analysis was performed using univariate and multivariate statistics. Results: During the period February 2009 till February 2013, 290 HCC patients presented to our multidisciplinary clinic. They were predominantly males and the mean age was $56.5{\pm}7.7years$. All cases developed HCC on top of cirrhosis that was mainly due to HCV (71%). Most of our patients were Child-Pugh A (50%) or B (36.9%) and commonly presented with small single lesions. Transarterial chemoembolization was the most common line of treatment used (32.4%). The overall survival was 79.9% at 6 months, 54.5% at 1 year and 22.4% at 2 years. Serum bilirubin, site of the tumor and type of treatment were the significant independent prognostic factors for survival. Conclusions: Our main prognostic variables are the bilirubin level, the bilobar hepatic affection and the application of specific treatment (either curative or palliative). Multidisciplinary clinics enhance better HCC management.

#Hepatocellular carcinoma #multidisciplinary #prognosis #survival

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Abdelaziz, Ashraf Omar

소속기관 Endemic medicine and Hepatogastroenterology Department, Faculty of Medicine, Cairo University