Colorectal Cancer Patient Characteristics, Treatment and Survival in Oman - a Single Center Study

Kumar, Shiyam; Burney, Ikram A; Zahid, Khawaja Farhan; Souza, Philomena Charlotte D; Belushi, Muna AL; Mufti, Taha Dawood; Meki, Waeil AL; Furrukh, Muhammad; Moundhri, Mansour S AL

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자료유형: 학술저널

저자정보: Kumar, Shiyam (Department of Medicine, Sultan Qaboos University Hospital) Burney, Ikram A (Department of Medicine, Sultan Qaboos University Hospital) Zahid, Khawaja Farhan (Department of Medicine, Sultan Qaboos University Hospital) Souza, Philomena Charlotte D (Nursing Directorate, Sultan Qaboos University Hospital) Belushi, Muna AL (Nursing Directorate, Sultan Qaboos University Hospital) Mufti, Taha Dawood (Department of Medicine, Sultan Qaboos University Hospital) Meki, Waeil AL (Department of Medicine, Sultan Qaboos University Hospital) Furrukh, Muhammad (Department of Medicine, Sultan Qaboos University Hospital) Moundhri, Mansour S AL (College of Medicine and Health Sciences, Sultan Qaboos University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제12호

발행연도: 2015.1

수록면: 4,853 - 4,858 (6page)

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Background: Colorectal cancer is the most common gastrointestinal cancer in Oman with an increasing incidence. We here report the presenting features, treatment outcomes and survival in a University hospital in Oman and compare our data with regional and international studies. Materials and Methods: Medical records of patients with colorectal cancer were reviewed retrospectively between June 2000 and December 2013 and were followed until June 2014. Results: A total of 162 patients were diagnosed with colorectal cancer. The majority were males (58.6%), with a median age of 56 years. Rectum was involved in 29.6% of patients, followed by ascending and sigmoid colon. The majority of patients had stage III (42.6%) and stage IV (32.7%) disease at presentation. K-Ras status was checked for 79 patients, and 41 (51.9%) featured the wild type. Median relapse free survival was 22 months. Median overall survival for all patients was 43 months. Observed 5 year overall survival (OS) for stages I, II and III was 100%, 60% and 60% respectively. On Log rank univariate analysis, age, BMI, diabetes, hypertension, metformin use, stage, clinical nodal status for rectal cancer, pathological T and nodal status, site of metastasis, surgical intervention, chemotherapy, radiotherapy, chemotherapy regimen, no of cycles of chemotherapy, response, RFS, site of recurrence and administration of $2^{nd}$ line chemotherapy were significant factors affecting OS. On Cox regression multivariate analysis none of the factors independently affected the OS. Conclusions: The majority of patients present with advanced disease and at young age. The survival rates are comparable to the published regional and international literature.

#Chemotherapy #olon cancer #metastasis #recurrence #Oman

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