Clinicopathologic Features of Breast Carcinomas Classified by Biomarkers and Correlation with Microvessel Density and VEGF Expression: A Study from Thailand

Chuangsuwanich, Tuenjai; Pongpruttipan, Tawatchai; O-charoenrat, Pornchai; Komoltri, Chulaluk; Watcharahirun, Suwapee; Sa-nguanraksa, Doonyapat

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자료유형: 학술저널

저자정보: Chuangsuwanich, Tuenjai (Department of Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University) Pongpruttipan, Tawatchai (Department of Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University) O-charoenrat, Pornchai (Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University) Komoltri, Chulaluk (Epidemiology Unit, Faculty of Medicine Siriraj Hospital, Mahidol University) Watcharahirun, Suwapee (Department of Pathology, Surin Hospital, Mueng District) Sa-nguanraksa, Doonyapat (Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제3호

발행연도: 2014.1

수록면: 1,187 - 1,192 (6page)

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Background: To correlate breast cancer subtypes with prognostic factors, microvessel density (MVD), vascular endothelial growth factor (VEGF) expression and clinical features. Materials and Methods: One hundred cases of primary breast carcinoma were classified using biomarkers on tissue microarray as: luminal A [estrogen receptor (ER)+, HER2-, $Ki-67{\leq}14%$], luminal B [ER+, HER2+ or ER+, HER2-, Ki-67>14%], HER2, triple negative basal-like (TNB) [any basal cytokeratins (CKs, 5, 14, 17) and/or endothelial growth factor receptor (EGFR) expression], and TN without such markers [TNN, null], and assessed for p53, vimentin, VEGF and CD31 immunoperoxidase. Results: Of the 100 cases (mean age, 51 years; mean tumor size, 3.2cm; 56% with nodal metastasis; 89 invasive ductal carcinomas, not otherwise specified, 4 invasive lobular carcinomas, 3 metaplastic carcinomas, and 4 other types) there were 39 luminal A, 18 luminal B, 18 HER2, 15 TNB and 10 TNN. The positivities of basal-like markers in the basal-like subtype were 78.3% for CK5, 40% for CK14, 20% for CK17, 46.7% for EGFR. There was no significant difference in age distribution, tumor size, degree of tubular formation, pleomorphism, lymphovascular invasion, nodal metastasis, MVD, VEGF expression and survival among subgroups. TNs demonstrated significantly higher tumor grade, mitotic count, Ki-67 index, p53 and vimentin and decreased overall survival compared with nonTN. Conclusions: The distribution of breast cancer subtypes in this study was similar to other Asian countries with a high prevalence of TN. The high grade character of TN was confirmed and CK5 expression was found to be common in our basal-like subtype. No significant elevation of MVD or VEGF expression was apparent.

#Ki-67 #Breast carcinoma #biomarker classification #triple negative #MVD #VEGF

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