Good Outcomes of Patients with Stage IB Endometrial Cancer with Surgery Alone

Rahatli, Samed; Dizdar, Omer; Kucukoztas, Nadire; Oguz, Arzu; Yalcin, Selim; Ozen, Ozlem; Reyhan, Nihan Haberal; Tarhan, Cagla; Yildiz, Ferah; Dursun, Polat; Altundag, Ozden; Ayhan, Ali

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자료유형: 학술저널

저자정보: Rahatli, Samed (Department of Medical Oncology, Baskent University Hospital) Dizdar, Omer (Department of Medical Oncology, Baskent University Hospital) Kucukoztas, Nadire (Department of Medical Oncology, Baskent University Hospital) Oguz, Arzu (Department of Medical Oncology, Baskent University Hospital) Yalcin, Selim (Department of Medical Oncology, Baskent University Hospital) Ozen, Ozlem (Department of Pathology, Baskent University Hospital) Reyhan, Nihan Haberal (Department of Pathology, Baskent University Hospital) Tarhan, Cagla (Department of Radiology, Baskent University Hospital) Yildiz, Ferah (Department of Radiation Oncology, Hacettepe University Institute of Oncology) Dursun, Polat (Department of Obstetrics and Gynecology, Baskent University Hospital) Altundag, Ozden (Department of Medical Oncology, Baskent University Hospital) Ayhan, Ali (Department of Obstetrics and Gynecology, Baskent University Hospital)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제9호

발행연도: 2014.1

수록면: 3,891 - 3,893 (3page)

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Background: Most patients with endometrial cancer have stage I disease. Adjuvant therapy in stage IB (formerly IC) endometrial cancer is controversial, treatment options including observation or brachytherapy/radiotherapy in grade 1-3 patients with or without chemotherapy. The purpose of this study was to assess the outcomes of our patients with stage IB endometrioid endometrial cancer. Materials and Methods: Sixty two patients with stage IB endometrial cancer and endometrioid histology were retrospectively evaluated. All patients were initially treated surgically by the same surgeon with comprehensive staging, i.e. total abdominal hysterectomy, bilateral salphingooopherectomy, bilateral pelvic and paraaortic lymph node dissection and omentectomy. Adjuvant radiotherapy was discussed with patients and utilized by those who accepted. Adjuvant chemotherapy was not given to any of the patients. Results: Median age was 62 (range, 42-95). Ninety percent of the patients had grade 1-2 disease. Thirteen patients (21%) received intra vaginal brachytherapy (IVBT) and one received whole pelvic radiotherapy (WPRT). Median follow-up time was 46 months (range, 9-77 months). Three patients experienced recurrence (4.8%), two of them died on follow-up and one was still alive at last visit. Two patients with recurrence had FIGO grade 2 tumors and one had a grade 3 tumor. Two patients (3.2%) died without evidence of recurrent disease. Relapse free survival at 5 years was 94.4% and overall survival was 93.1%. Conclusions: Patients with stage IB disease in our study demonstrated relatively low recurrence rates although the majority of them received no adjuvant treatment. Surgery alone may be sufficient for most patients with this stage of endometrial cancer.

#Endometrial cancer #stage IB #surgery #chemotherapy #radiotherapy

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