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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 153 - 166 (14page)
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A variety of ligands differ in their capacity to bind the receptor, elicit gene expression, and modulate physiological responses. Such receptors include Toll-like receptors (TLRs), which recognize various patterns of pathogens and lead to primary innate immune activation against invaders, and G-protein coupled receptors (GPCRs), whose interaction with their cognate ligands activates heterotrimeric G proteins and regulates specific downstream effectors, including immuno-stimulating molecules. Once TLRs are activated, they lead to the expression of hundreds of genes together and bridge the arm of innate and adaptive immune responses. We characterized the gene expression profile of Toll-like receptor 4 (TLR4) in RAW 264.7 cells when it bound with its ligand, 2-keto-3-deoxyoctonate (KDO), the active part of lipopolysaccharide. In addition, to determine the network communications among the TLR, Janus kinase (JAK)/signal transducer and activator of transcription (STAT), and GPCR, we tested RAW 264.7 cells with KDO, interferon-${\beta}$, or cAMP analog 8-Br. The ligands were also administered as a pair of double and triple combinations.
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참고문헌 (67)
참고문헌 신청
Jayalakshmi Krishnan / 2007 / Toll-like receptor signal transduction / Experimental and Molecular Medicine 39(4):421~438
Basith S / 2011 / Toll-like receptor modulators: a patent review / Expert Opin Ther Pat 21:927~944
Raetz CR / 2006 / Kdo2-Lipid A of Escherichia coli, a defined endotoxin that activates macrophages via TLR-4 / J Lipid Res 47:1097~1111
Kim EY / 2010 / ATF3 plays a key role in Kdo2-lipid A-induced TLR4-dependent gene expression via NF-kappaB activation / PLoS One 5:14181
Dunne A / 2003 / The interleukin-1 receptor/Toll-like receptor superfamily: signal transduction during inflammation and host defense / Sci STKE 2003:3
Basith S / 2011 / Toll-like receptor modulators: a patent review / Expert Opin Ther Pat 21:927~944
Raetz CR / 2006 / Kdo2-Lipid A of Escherichia coli, a defined endotoxin that activates macrophages via TLR-4 / J Lipid Res 47:1097~1111
Kim EY / 2010 / ATF3 plays a key role in Kdo2-lipid A-induced TLR4-dependent gene expression via NF-kappaB activation / PLoS One 5:14181
Dunne A / 2003 / The interleukin-1 receptor/Toll-like receptor superfamily: signal transduction during inflammation and host defense / Sci STKE 2003:3
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