지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 137 - 145 (9page)
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초록· 키워드
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Selective sweep can cause genetic differentiation across populations, which allows for the identification of possible causative regions/genes underlying important traits. The pig has experienced a long history of allele frequency changes through artificial selection in the domestication process. We obtained an average of 329,482,871 sequence reads for 24 pigs from three pig breeds: Yorkshire (n = 5), Landrace (n = 13), and Duroc (n = 6). An average read depth of 11.7 was obtained using whole-genome resequencing on an Illumina HiSeq2000 platform. In this study, cross-population extended haplotype homozygosity and cross-population composite likelihood ratio tests were implemented to detect genes experiencing positive selection for the genome-wide resequencing data generated from three commercial pig breeds. In our results, 26, 7, and 14 genes from Yorkshire, Landrace, and Duroc, respectively were detected by two kinds of statistical tests. Significant evidence for positive selection was identified on genes ST6GALNAC2 and EPHX1 in Yorkshire, PARK2 in Landrace, and BMP6, SLA-DQA1, and PRKG1 in Duroc. These genes are reportedly relevant to lactation, reproduction, meat quality, and growth traits. To understand how these single nucleotide polymorphisms (SNPs) related positive selection affect protein function, we analyzed the effect of non-synonymous SNPs. Three SNPs (rs324509622, rs80931851, and rs80937718) in the SLA-DQA1 gene were significant in the enrichment tests, indicating strong evidence for positive selection in Duroc. Our analyses identified genes under positive selection for lactation, reproduction, and meat-quality and growth traits in Yorkshire, Landrace, and Duroc, respectively.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Hafez ES / 1968 / Adaptation of Domestic Animals / Lea & Febiger
Larson G. / 2007 / Ancient DNA, pig domestication, and the spread of the Neolithic into Europe / Proc Natl Acad Sci USA 104:15276~15281
Williams NH. / 1997 / Effect of chronic immune system activation on the rate, efficiency, and composition of growth and lysine needs of pigs fed from 6 to 27 kg / J Anim Sci 75:2463~2471
Wilkinson S. / 2013 / Signatures of diversifying selection in European pig breeds / PLoS Genet 9:e1003453
Church PC. / 2012 / EXP-PAC : providing comparative analysis and storage of next generation gene expression data / Genomics 100:8~13
Larson G. / 2007 / Ancient DNA, pig domestication, and the spread of the Neolithic into Europe / Proc Natl Acad Sci USA 104:15276~15281
Williams NH. / 1997 / Effect of chronic immune system activation on the rate, efficiency, and composition of growth and lysine needs of pigs fed from 6 to 27 kg / J Anim Sci 75:2463~2471
Wilkinson S. / 2013 / Signatures of diversifying selection in European pig breeds / PLoS Genet 9:e1003453
Church PC. / 2012 / EXP-PAC : providing comparative analysis and storage of next generation gene expression data / Genomics 100:8~13
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