지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 35 - 41 (7page)
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Metformin is widely used for T2D therapy but its cellular mechanism of action is undefined. Recent studies on the mechanism of metformin in T2D have demonstrated involvement of the immune system. Current immunotherapies focus on the potential of immunomodulatory strategies for the treatment of T2D. In this study, we examined the effects of metformin on the antigen-presenting function of antigen-presenting cells (APCs). Metformin decreased both MHC class I and class II-restricted presentation of OVA and suppressed the expression of both MHC molecules and co-stimulatory factors such as CD54, CD80, and CD86 in DCs, but did not affect the phagocytic activity toward exogenous OVA. The class II-restricted OVA presentation-regulating activity of metformin was also confirmed using mice that had been injected with metformin followed by soluble OVA. These results provide an understanding of the mechanisms of the T cell response-regulating activity of metformin through the inhibition of MHC-restricted antigen presentation in relation to its actions on APCs.
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참고문헌 (41)
참고문헌 신청
Bailey, C. J. / 1996 / Metformin / N. Engl. J. Med 334:574~579
Banchereau, J. / 2000 / Immunobiology of dendritic cells / Annu. Rev. Immunol 18:767~811
Bevan, M. J. / 1976 / Cross-priming for a secondary cytotoxic response to minor H antigens with H-2 congenic cells which do not cross-react in the cytotoxic assay / J. Exp. Med 143:1283~1288
Brossart, P. / 1997 / Presentation of exogenous protein antigens on major histocompatibility complex class I molecules by dendritic cells: pathway of presentation and regulation by cytokines / Blood 90:1594~1599
DeFronzo, R. A. / 1988 / The triumvirate: b-cell, muscle, liver: a collusion responsible for NIDDM / Diabetes 37:667~687
Banchereau, J. / 2000 / Immunobiology of dendritic cells / Annu. Rev. Immunol 18:767~811
Bevan, M. J. / 1976 / Cross-priming for a secondary cytotoxic response to minor H antigens with H-2 congenic cells which do not cross-react in the cytotoxic assay / J. Exp. Med 143:1283~1288
Brossart, P. / 1997 / Presentation of exogenous protein antigens on major histocompatibility complex class I molecules by dendritic cells: pathway of presentation and regulation by cytokines / Blood 90:1594~1599
DeFronzo, R. A. / 1988 / The triumvirate: b-cell, muscle, liver: a collusion responsible for NIDDM / Diabetes 37:667~687
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