지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 214 - 219 (6page)
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초록· 키워드
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This research was designed to determine what components of Gardenia jasminoides play a major role in inhibiting the enzymes related antidepressant activity of this plant. In our previous research, the ethyl acetate fraction of G. jasminosides fruits inhibited the activities of both monoamine oxidase-A (MAO-A) and monoamine oxidase-B (MAO-B), and oral administration of the ethanolic extract slightly increased serotonin concentrations in the brain tissues of rats and decreased MAO-B activity. In addition, we found through in vitro screening test that the ethyl acetate fraction showed modest inhibitory activity on dopamine-${\beta}$ hydroxylase (DBH). The bioassay-guided fractionation led to the isolation of five bio-active compounds, protocatechuic acid (1), geniposide (2), 6'-O-trans-p-coumaroylgeniposide (3), 3,5-dihydroxy-1,7-bis(4-hydroxyphenyl) heptanes (4), and ursolic acid (5), from the ethyl acetate fraction of G. jasminoides fruits. The isolated compounds showed different inhibitory potentials against MAO-A, -B, and DBH. Protocatechuic acid showed potent inhibition against MAO-B ($IC_{50}$ $300{\mu}mol/L$) and DBH ($334{\mu}mol/L$), exhibiting weak MAO-A inhibition (2.41 mmol/L). Two iridoid glycosides, geniposide ($223{\mu}mol/L$) and 6'-O-trans-p-coumaroylgeniposide ($127{\mu}mol/L$), were selective MAO-B inhibitor. Especially, 6'-O-trans-p-coumaroylgeniposide exhibited more selective MAO-B inhibition than deprenyl, well-known MAO-B inhibitor for the treatment of early-stage Parkinson's disease. The inhibitory activity of 3,5-dihydroxy-1,7-bis (4-hydroxyphenyl) heptane was strong for MAO-B ($196{\mu}mol/L$), modest for MAO-A ($400{\mu}mol/L$), and weak for DBH ($941{\mu}mol/L$). Ursolic acid exhibited significant inhibition of DBH ($214{\mu}mol/L$), weak inhibition of MAO-B ($780{\mu}mol/L$), and no inhibition against MAO-A. Consequently, G. jasminoides fruits are considerable for development of biofunctional food materials for the combination treatment of depression and neurodegenerative disorders.
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참고문헌 (27)
참고문헌 신청
Dinda, B. / 2007 / Naturally occurring iridoids. A review, part 1 / Chem. Pharm. Bull (Tokyo) 55:159~222
Guan, S. / 2009 / Protocatechuic acid promotes cell proliferation and reduces basal apoptosis in cultured neural stem cells / Toxicol In Vitro 23:201~208
Han, Y. N. / 2001 / Monoamine oxidase B inhibitors from the fruits of Opuntia fi cus-indica var. saboten / Arch. Pharm. Res 24:51~54
Han, Y. N. / 1997 / Compounds having dopamine beta-hydroxylase inhibitory activity / Patent WO 1997029076
Han, Y. N. / 1987 / Studies on the monoamine oxidase inhibitors of medicinal plants I. isolation of MAO-B inhibitors from Chrysanthemum indicum / Arch. Pharm. Res 10:142~147
Guan, S. / 2009 / Protocatechuic acid promotes cell proliferation and reduces basal apoptosis in cultured neural stem cells / Toxicol In Vitro 23:201~208
Han, Y. N. / 2001 / Monoamine oxidase B inhibitors from the fruits of Opuntia fi cus-indica var. saboten / Arch. Pharm. Res 24:51~54
Han, Y. N. / 1997 / Compounds having dopamine beta-hydroxylase inhibitory activity / Patent WO 1997029076
Han, Y. N. / 1987 / Studies on the monoamine oxidase inhibitors of medicinal plants I. isolation of MAO-B inhibitors from Chrysanthemum indicum / Arch. Pharm. Res 10:142~147
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