지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 222 - 228 (7page)
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Although the role of ${\alpha}$-synuclein aggregation on Parkinson's disease is relatively well known, the physiological role and the regulatory mechanism governing the expression of ${\alpha}$-synuclein are unclear yet. We recently reported that ${\alpha}$-synuclein is expressed and secreted from cultured astrocytes. In this study, we investigated the effect of valproic acid (VPA), which has been suggested to provide neuroprotection by increasing ${\alpha}$-synuclein in neuron, on ${\alpha}$-synuclein expression in rat primary astrocytes. VPA concentration-dependently increased the protein expression level of ${\alpha}$-synuclein in cultured rat primary astrocytes with concomitant increase in mRNA expression level. Likewise, the level of secreted ${\alpha}$-synuclein was also increased by VPA. VPA increased the phosphorylation of Erk1/2 and JNK and pretreatment of a JNK inhibitor SP600125 prevented the VPA-induced increase in ${\alpha}$-synuclein. Whether the increased ${\alpha}$-synuclein in astrocytes is involved in the reported neuroprotective effects of VPA awaits further investigation.
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참고문헌 (41)
참고문헌 신청
Alves Da Costa, C. / 2002 / Alpha-synuclein lowers p53-dependent apoptotic response of neuronal cells. Abolishment by 6-hydroxydopamine and implication for Parkinson's disease / J. Biol. Chem 277:50980~50984
Bennett, M. C. / 1999 / Degradation of alpha-synuclein by proteasome / J. Biol. Chem 274:33855~33858
Björkblom, B. / 2012 / c-Jun N-terminal kinase phosphorylation of MARCKSL1 determines actin stability and migration in neurons and in cancer cells / Mol. Cell. Biol 32:3513~3526
Cao, C. / 2009 / SIRT1 confers protection against UVB- and H2O2-induced cell death via modulation of p53 and JNK in cultured skin keratinocytes / J. Cell. Mol. Med 13:3632~3643
Catalano, M. G. / 2007 / Valproic acid enhances tubulin acetylation and apoptotic activity of paclitaxel on anaplastic thyroid cancer cell lines / Endocr. Relat. Cancer 14:839~845
Bennett, M. C. / 1999 / Degradation of alpha-synuclein by proteasome / J. Biol. Chem 274:33855~33858
Björkblom, B. / 2012 / c-Jun N-terminal kinase phosphorylation of MARCKSL1 determines actin stability and migration in neurons and in cancer cells / Mol. Cell. Biol 32:3513~3526
Cao, C. / 2009 / SIRT1 confers protection against UVB- and H2O2-induced cell death via modulation of p53 and JNK in cultured skin keratinocytes / J. Cell. Mol. Med 13:3632~3643
Catalano, M. G. / 2007 / Valproic acid enhances tubulin acetylation and apoptotic activity of paclitaxel on anaplastic thyroid cancer cell lines / Endocr. Relat. Cancer 14:839~845
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