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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 50 - 56 (7page)
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WIN-34B showed analgesic and anti-inflammatory effects in various animal models of pain and osteoarthritis. However, the molecular mechanism by which WIN-34B inhibits pain and inflammation in vivo remains to be elucidated. We investigated the molecular mechanisms of the actions of WIN-34B using various in vitro models using fibroblast-like synoviocytes from patients with rheumatoid arthritis (RA FLSs), RAW264.7 cells and peritoneal macrophages. WIN-34B inhibited the level of IL-6, $PGE_2$, and MMP-13 in IL-$1{\beta}$-stimulated RA FLSs in a dose-dependent manner. The mRNA levels were also inhibited by WIN-34B. The level of $PGE_2$, NO, IL-$1{\beta}$, and TNF-${\alpha}$ were inhibited by WIN-34B at different concentrations in LPS-stimulated RAW264.7 cells. The production of NO and $PGE_2$ was inhibited by WIN-34B in a dose-dependent manner in LPS-stimulated peritoneal macrophages. All of these effects were comparable to the positive control, celecoxib or indomethacin. I${\kappa}B$B signaling pathways were inhibited by WIN-34B, and the migration of NF-${\kappa}B$ into the nucleus was inhibited, which is consistent with the degradation of $I{\kappa}B-{\alpha}$. Taken together, the results suggest that WIN-34B has potential as a therapeutic drug to reduce pain and inflammation by inhibiting the production of pro-inflammatory mediators.
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참고문헌 (27)
참고문헌 신청
Ameye, L. G. / 2006 / Osteoarthritis and nutrition. From nutraceuticals to functional foods: a systematic review of the scientifi c evidence / Arthritis. Res. Ther 8:R127
Bhatia, H. S. / 2008 / Mangiferin inhibits cyclooxygenase-2 expression and prostaglandin E2 production in activated rat microglial cells / Arch. Biochem. Biophys 477:253~258
Choi, H. M. / 2009 / Adiponectin may contribute to synovitis and joint destruction in rheumatoid arthritis by stimulating vascular endothelial growth factor, matrix metalloproteinase- 1, and matrix metalloproteinase-13 expression in fi broblast-like synoviocytes more than proinfl ammatory mediators / Arthritis. Res. Ther 11:R161.
Choi, H. M. / 2010 / Differential effect of IL-1β and TNFα on the production of IL-6, IL-8 and PGE2 in fi broblast-like synoviocytes and THP-1 macrophages / Rheumatol. Int 30:1025~1033
Dat, N. T. / 2010 / An isoaurone and other constituents from Trichosanthes kirilowii seeds inhibit hypoxia-inducible factor-1 and nuclear factor-kappaB / J. Nat. Prod 73:1167~1169
Bhatia, H. S. / 2008 / Mangiferin inhibits cyclooxygenase-2 expression and prostaglandin E2 production in activated rat microglial cells / Arch. Biochem. Biophys 477:253~258
Choi, H. M. / 2009 / Adiponectin may contribute to synovitis and joint destruction in rheumatoid arthritis by stimulating vascular endothelial growth factor, matrix metalloproteinase- 1, and matrix metalloproteinase-13 expression in fi broblast-like synoviocytes more than proinfl ammatory mediators / Arthritis. Res. Ther 11:R161.
Choi, H. M. / 2010 / Differential effect of IL-1β and TNFα on the production of IL-6, IL-8 and PGE2 in fi broblast-like synoviocytes and THP-1 macrophages / Rheumatol. Int 30:1025~1033
Dat, N. T. / 2010 / An isoaurone and other constituents from Trichosanthes kirilowii seeds inhibit hypoxia-inducible factor-1 and nuclear factor-kappaB / J. Nat. Prod 73:1167~1169
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