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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 323 - 331 (9page)
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초록· 키워드
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TGF-${\beta}$ pathway is being extensively evaluated as a potential therapeutic target. The transforming growth factor-${\beta}$ (TGF-${\beta}$) signaling pathway has the dual role in both tumor suppression and tumor promotion. To design cancer therapeutics successfully, it is important to understand TGF-${\beta}$ related functional contexts. This review discusses the molecular mechanism of the TGF-${\beta}$ pathway and describes the different ways of tumor suppression and promotion by TGF-${\beta}$. In the last part of the review, the data on targeting TGF-${\beta}$ pathway for cancer treatment is assessed. The TGF-${\beta}$ inhibitors in pre-clinical studies, and Phase I and II clinical trials are updated.
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참고문헌 (92)
참고문헌 신청
Akiyama, Y. / 1997 / Transforming growth factor beta type II receptor gene mutations in adenomas from hereditary nonpolyposis colorectal cancer / Gastroenterology 112:33~39
Arteaga, C. / 1993 / Anti-transforming growth factor (TGF)-beta antibodies inhibit breast cancer cell tumorigenicity and increase mouse spleen natural killer cell activity. Implications for a possible role of tumor cell/host TGF-beta interactions in human breast cancer progression / J. Clin. Invest 92:2569~2576
Bandyopadhyay, A. / 2006 / Inhibition of pulmonary and skeletal metastasis by a transforming growth factor-β type I receptor kinase inhibitor / Cancer Res 66:6714~6721
Biswas, S. / 2007 / Inhibition of TGF-β with neutralizing antibodies prevents radiation-induced acceleration of metastatic cancer progression / J. Clin. Invest 117:1305~1313
Bueno, L. / 2008 / Semi-mechanistic modelling of the tumour growth inhibitory effects of LY2157299, a new type I receptor TGF-β kinase antagonist, in mice / Eur. J. Cancer 44:142~150
Arteaga, C. / 1993 / Anti-transforming growth factor (TGF)-beta antibodies inhibit breast cancer cell tumorigenicity and increase mouse spleen natural killer cell activity. Implications for a possible role of tumor cell/host TGF-beta interactions in human breast cancer progression / J. Clin. Invest 92:2569~2576
Bandyopadhyay, A. / 2006 / Inhibition of pulmonary and skeletal metastasis by a transforming growth factor-β type I receptor kinase inhibitor / Cancer Res 66:6714~6721
Biswas, S. / 2007 / Inhibition of TGF-β with neutralizing antibodies prevents radiation-induced acceleration of metastatic cancer progression / J. Clin. Invest 117:1305~1313
Bueno, L. / 2008 / Semi-mechanistic modelling of the tumour growth inhibitory effects of LY2157299, a new type I receptor TGF-β kinase antagonist, in mice / Eur. J. Cancer 44:142~150
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