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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 416 - 424 (9page)
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초록· 키워드
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A series of N,N'-substituted iminodiacetamide derivatives was synthesized and evaluated their inhibitory effects on the histamine-induced smooth muscle contraction in guinea-pig ileum and on the histamine release from IgE-sensitized RBL-2H3 cells (rat basophilic leukemia cell line). Compounds A3, A4 and A5 which have 1-(4-chlorobenzhydryl) piperazine moiety, showed both moderate antihistamine activity and histamine release inhibitory activity.
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참고문헌 (25)
참고문헌 신청
Akah, P. A / 1997 / Evaluation of Nigerian traditional medicine: effects of Gakani, a herbal anti-asthmatic drug / J. Ethnopharmacol 55:87~92
Baroody, F. M / 2000 / Antiallergic effects of H1 receptor antagonists / Allergy 55:17~27
Berthon, B / 1994 / In vitro inhibition, by loratadine and descarboxyethoxyloratadine, of histamine release from human basophils, and of histamine release and intracellular calcium fluxes in rat basophilic leukemia cells (RBL-2H3) / Biochem. Pharmacol 47:789~794
Boger, D. L / 1999 / Solution phase combinatorial synthesis of biaryl libraries employing heterogeneous conditions for catalysis and isolation with size exclusion chromatograpy for purification / J. Org. Chem 64:2422~2427
Chand, N / 1985 / Inhibition of allergic histamine release by azelastine and selected antiallergic drugs from rabbit leucocytes / Int. Arch. Allergy Appl. Immunol 77:451~455
Baroody, F. M / 2000 / Antiallergic effects of H1 receptor antagonists / Allergy 55:17~27
Berthon, B / 1994 / In vitro inhibition, by loratadine and descarboxyethoxyloratadine, of histamine release from human basophils, and of histamine release and intracellular calcium fluxes in rat basophilic leukemia cells (RBL-2H3) / Biochem. Pharmacol 47:789~794
Boger, D. L / 1999 / Solution phase combinatorial synthesis of biaryl libraries employing heterogeneous conditions for catalysis and isolation with size exclusion chromatograpy for purification / J. Org. Chem 64:2422~2427
Chand, N / 1985 / Inhibition of allergic histamine release by azelastine and selected antiallergic drugs from rabbit leucocytes / Int. Arch. Allergy Appl. Immunol 77:451~455
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