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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 472 - 476 (5page)
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초록· 키워드
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Hypercholesterolemia indirectly increases the risk of arterial and venous thrombosis by enhancing the ability of platelets to aggregate. Yacon (Smallanthus sonchifolius) is composed of fructooligosaccharides, proteins, minerals and phenolic compounds, and has potential benefits for the management of diabetes. This study investigated whether the consumption of yacon in the diet inhibits platelet aggregation under hypercholesterolemic conditions. Male New Zealand white rabbits were fed one of five dietary interventions: a normal control diet, 0.5% cholesterol diet, 0.5% cholesterol diet+a low dose of yacon (0.5 g/kg body weight given orally each day), 0.5% cholesterol diet+a high dose of yacon (2.5 g/kg body weight given orally each day), or a 0.5% cholesterol diet+lovastatin (2 mg/kg body weight given orally each day). After 8 weeks, blood was collected to measure the amount of collagen- and thrombin-induced platelets present. Yacon inhibited the platelet aggregation induced by low doses of agonists (0.5 ${\mu}g/mL$ collagen and 0.02 units/ml thrombin) in a concentration-dependent manner. In addition, yacon concentration-dependently inhibited collagen-induced arachidonic acid liberation. Moreover, n-hexane, chloroform and ethyl acetate fractions showed a marked and selective inhibition of the platelet aggregation induced by collagen, again in a dose-dependent manner. These fractions, especially that of chloroform, significantly suppressed platelet aggregation. The results of this study demonstrate that when yacon is added to a cholesterol-enriched diet, cholesterol-induced platelet aggregation returns to control levels. This may also be beneficial in preventing atherosclerosis and reducing risk factors for coronary artery disease and stroke.
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참고문헌 (25)
참고문헌 신청
Bocan, T. M / 1986 / Ultrastructure of the human aortic fi brolipid lesion. Formation of the atherosclerotic lipid-rich core / Am. J. Pathol 123:413~424
Bodin, S / 2001 / Production of phosphatidylinositol 3,4,5-trisphosphate and phosphatidic acid in platelet rafts: evidence for a critical role of cholesterol-enriched domains in human platelet activation / Biochemistry 40:15290~15299
Fernandez-Ortiz, A / 1994 / Characterization of the relative thrombogenicity of atherosclerotic plaque components: implications for consequences of plaque rupture / J. Am. Coll. Cardiol 23:1562~1569
Fuster, V / 1992 / The pathogenesis of coronary artery disease and the acute coronary syndromes (1) / Engl. J. Med 326:242~250
Grgurevich, S / 2003 / Role of in vitro cholesterol depletion in mediating human platelet aggregation / J. Thromb. Haemost 1:578~586
Bodin, S / 2001 / Production of phosphatidylinositol 3,4,5-trisphosphate and phosphatidic acid in platelet rafts: evidence for a critical role of cholesterol-enriched domains in human platelet activation / Biochemistry 40:15290~15299
Fernandez-Ortiz, A / 1994 / Characterization of the relative thrombogenicity of atherosclerotic plaque components: implications for consequences of plaque rupture / J. Am. Coll. Cardiol 23:1562~1569
Fuster, V / 1992 / The pathogenesis of coronary artery disease and the acute coronary syndromes (1) / Engl. J. Med 326:242~250
Grgurevich, S / 2003 / Role of in vitro cholesterol depletion in mediating human platelet aggregation / J. Thromb. Haemost 1:578~586
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