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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 68 - 74 (7page)
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초록· 키워드
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Anthocyanins have received growing attention as dietary antioxidants for the prevention of oxidative damage. Astrocytes, which are specialized glial cells, exert numerous essential, complex functions in both healthy and diseased central nervous system (CNS) through a process known as reactive astrogilosis. Therefore, the maintenance of glial cell viability may be important because of its role as a key modulator of neuropathological events. The aim of this study was to investigate the effect of anthocyanin on the survival of glial cells exposed to oxidative stress. Our results demonstrated that anthocyanin extracts from black soybean increased survival of U87 glioma cells in a dose dependent manner upon oxygen-glucose deprivation (OGD), accompanied by decrease levels of reactive oxygen species (ROS). While treatment cells with anthocyanin extracts or OGD stress individually activated autophagy induction, the effect was signifi cantly augmented by pretreatment cells with anthocyanin extracts prior to OGD. The contribution of autophagy induction to the protective effects of anthocyanin was verifi ed by the observation that silencing the Atg5 expression, an essential regulator of autophagy induction, reversed the cytoprotective effect of anthocyanin extracts against OGD stress. Treatment of U87 cells with rapamycin, an autophagy inducer, increased cell survival upon OGD stress comparable to anthocyanin, indicating that autophagy functions as a survival mechanism against oxidative stress-induced cytotoxicity in glial cells. Our results, therefore, provide a rationale for the use of anthocyanin as a preventive agent for brain dysfunction caused by oxidative damage, such as a stroke.
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참고문헌 (44)
참고문헌 신청
Bonini, P. / 2004 / Oxidative stress induces p53-mediated apoptosis in glia: p53 transcription-independent way to die / J. Neurosci. Res 75:83~95
Budd, S. L. / 1998 / Calcium tsunamis: do astrocytes transmit cell death messages via gap junctions during ischemia? / Nat. Neurosci 1:431~432
Byun, Y. J. / 2009 / Hydrogen peroxide induces autophagic cell death in C6 glioma cells via BNIP3-mediated suppression of the mTOR pathway / Neurosci. Lett 461:131~135
Casadesus, G. / 2004 / Modulation of hippocampal plasticity and cognitive behavior by short-term blueberry supplementation in aged rats / Nutr. Neurosci 7:309~316
Chen, Y. / 2001 / Astrocytes protect neurons from nitric oxide toxicity by a glutathione-dependent mechanism / J. Neurochem 77:1601~1610
Budd, S. L. / 1998 / Calcium tsunamis: do astrocytes transmit cell death messages via gap junctions during ischemia? / Nat. Neurosci 1:431~432
Byun, Y. J. / 2009 / Hydrogen peroxide induces autophagic cell death in C6 glioma cells via BNIP3-mediated suppression of the mTOR pathway / Neurosci. Lett 461:131~135
Casadesus, G. / 2004 / Modulation of hippocampal plasticity and cognitive behavior by short-term blueberry supplementation in aged rats / Nutr. Neurosci 7:309~316
Chen, Y. / 2001 / Astrocytes protect neurons from nitric oxide toxicity by a glutathione-dependent mechanism / J. Neurochem 77:1601~1610
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