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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 288 - 295 (8page)
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초록· 키워드
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Amyloid beta ($A{\beta}$)-induced neurotoxicity is a major pathological mechanism of Alzheimer's disease (AD). In this study, we investigated the inhibitory effect of L-theanine, a component of green tea (Camellia sinensis) on $A{\beta}_{1-42}$-induced neurotoxicity and oxidative damages of macromolecules. L-theanine inhibited $A{\beta}_{1-42}$-induced generation of reactive oxygen species, and activation of extracellular signal-regulated kinase and p38 mitogenic activated protein kinase as well as the activity of nuclear factor kappa-B. L-theanine also signifi cantly reduced oxidative protein and lipid damage, and elevated glutathione level. Consistent with the reduced neurotoxic signals, L-theanine (10-50 ${\mu}g$/ml) concomitantly attenuated $A{\beta}_{1-42}$ (5 ${\mu}M$)-induced neurotoxicity in SK-N-MC and SK-N-SH human neuroblastoma cells. These data indicate that L-theanine on $A{\beta}$-induced neurotoxicity prevented oxidative damages of neuronal cells, and may be useful in the prevention and treatment of neurodegenerative disease like AD.
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참고문헌 (43)
참고문헌 신청
Abdul, H. M / 2008 / Oxidative damage in brain from human mutant APP/PS-1 double knock-in mice as a function of age / Free Radic. Biol. Med
Ayoub, S / 2006 / Induction of neutral endopeptidase (NEP) activity of SK-N-SH cells by natural compounds from green tea / J. Pharm. Pharmacol 58:495~501
Bai, Y / 2008 / p75 (NTR) activation of NFkappaB is involved in PrP106-126-induced apoptosis in mouse neuroblastoma cells / Neurosci. Res 62:9~14
Buggia-Prevot, V / 2008 / NFkappaB-dependent control of BACE1 promoter transactivation by Abeta42 / J. Biochem 283:10037~10047
Butterfi eld, D. A / 2002 / Lipid peroxidation and protein oxidation in Alzheimer’s disease brain potential cause and consequences involving amyloid-peptide associated free radical oxidative stress / Free Radic. Biol. Med 32:1050~1060
Ayoub, S / 2006 / Induction of neutral endopeptidase (NEP) activity of SK-N-SH cells by natural compounds from green tea / J. Pharm. Pharmacol 58:495~501
Bai, Y / 2008 / p75 (NTR) activation of NFkappaB is involved in PrP106-126-induced apoptosis in mouse neuroblastoma cells / Neurosci. Res 62:9~14
Buggia-Prevot, V / 2008 / NFkappaB-dependent control of BACE1 promoter transactivation by Abeta42 / J. Biochem 283:10037~10047
Butterfi eld, D. A / 2002 / Lipid peroxidation and protein oxidation in Alzheimer’s disease brain potential cause and consequences involving amyloid-peptide associated free radical oxidative stress / Free Radic. Biol. Med 32:1050~1060
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