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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 267 - 274 (8page)
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Drug development and preclinical trials are challenging processes and more than 80% to 90% of drug candidates fail to gain approval from the United States Food and Drug Administration. Predictive and efficient tools are required to discover high quality targets and increase the probability of success in the process of new drug development. One such solution to the challenges faced in the development of new drugs and combination therapies is the use of low-cost and experimentally manageable in vivo animal models. Since the 1980's, scientists have been able to genetically modify the mouse genome by removing or replacing a specific gene, which has improved the identification and validation of target genes of interest. Now genetically engineered mouse models (GEMMs) are widely used and have proved to be a powerful tool in drug discovery processes. This review particularly covers recent fascinating technologies for drug discovery and preclinical trials, targeted transgenesis and RNAi mouse, including application and combination of inducible system. Improvements in technologies and the development of new GEMMs are expected to guide future applications of these models to drug discovery and preclinical trials.
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참고문헌 (55)
참고문헌 신청
Abate-Shen, C / 2006 / A new generation of mouse models of cancerfor translational research / Clin. Cancer Res 12:5274~5276
Beard, C / 2006 / Effi cient method to generate single-copy transgenic miceby site-specifi c integration in embryonic stem cells / Genesis 44:23~28
Begley, C. G / 2012 / Drug development: Raise standardsfor preclinical cancer research / Nature 483:531~533
Belteki, G / 2005 / Conditional andinducible transgene expression in mice through the combinatorialuse of Cre-mediated recombination and tetracycline induction / Nucleic Acids Res 33:e51
Bolon, B / 2004 / Genetically engineered animals in drug discovery anddevelopment: a maturing resource for toxicologic research / BasicClin. Pharmacol. Toxicol 95:154~161
Beard, C / 2006 / Effi cient method to generate single-copy transgenic miceby site-specifi c integration in embryonic stem cells / Genesis 44:23~28
Begley, C. G / 2012 / Drug development: Raise standardsfor preclinical cancer research / Nature 483:531~533
Belteki, G / 2005 / Conditional andinducible transgene expression in mice through the combinatorialuse of Cre-mediated recombination and tetracycline induction / Nucleic Acids Res 33:e51
Bolon, B / 2004 / Genetically engineered animals in drug discovery anddevelopment: a maturing resource for toxicologic research / BasicClin. Pharmacol. Toxicol 95:154~161
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