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논문 기본 정보

자료유형
학술저널
저자정보
Yang, Goeun (College of Veterinary Medicine, Chungbuk National University) Park, Dongsun (College of Veterinary Medicine, Chungbuk National University) Lee, Sun Hee (College of Veterinary Medicine, Chungbuk National University) Bae, Dae-Kwon (College of Veterinary Medicine, Chungbuk National University) Yang, Yun-Hui (College of Veterinary Medicine, Chungbuk National University) Kyung, Jangbeen (College of Veterinary Medicine, Chungbuk National University) Kim, Dajeong (College of Veterinary Medicine, Chungbuk National University) Choi, Ehn-Kyoung (College of Veterinary Medicine, Chungbuk National University) Hong, Jin Tae (College of Pharmacy, Chungbuk National University) Jeong, Heon-Sang (Department Food Science and Technology, Chungbuk National University) Kim, Hee Jung (Department of Marine Molecular Biotechnology, College of Life Science, Gangneung-Wonju National University) Jang, Su Kil (Department of Marine Molecular Biotechnology, College of Life Science, Gangneung-Wonju National University) Joo, Seong Soo (Department of Marine Molecular Biotechnology, College of Life Science, Gangneung-Wonju National University) Kim, Yun-Bae (College of Veterinary Medicine, Chungbuk Natio)
저널정보
한국응용약물학회 Biomolecules & Therapeutics(구 응용약물학회지) Biomolecules & therapeutics 제21권 제6호
발행연도
2013.1
수록면
454 - 461 (8page)

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The neuroprotective effects of a butanol fraction of white rose petal extract (WRPE-BF) were investigated in a middle cerebral artery occlusion (MCAO) model. Seven week-old male rats were orally administered WRPE-BF for 2 weeks and subjected to MCAO for 2 h, followed by reperfusion. Twenty-four h later, MCAO-induced behavioral dysfunctions were markedly improved in a dose-dependent manner by pretreatment with WRPE-BF. Moreover, higher dose of WRPE-BF not only decreased infarction area but also effectively reduced astrogliosis. The expression of inducible nitric oxide synthase, cyclooxygenase-2, and glial fibrillary acidic protein in MCAO model were markedly inhibited by WRPE-BF treatment. Notably, WRPE-BF decreased nitricoxide and malondialdehyde levels in the striatum and subventricular zone of stroke-challenged brains. These data suggested that WRPE-BF may exert its neuroprotective effects via anti-oxidative and anti-inflammatory activities against ischemia-reperfusion brain injury and could be a good candidate as a therapeutic target for ischemic stroke.

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