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Mass spectrometry-based metabolomic study of traditional Doenjang effects against hepatic fibrosis
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논문 기본 정보

Type
Academic journal
Author
Lee, Jang-Eun (Traditional Alcoholic Beverages Research Team, Korea Food Research Institute) Park, So Rim (Division of Nutrition and Metabolism Research, Korea Food Research Institute) Lim, Seong Il (Division of Nutrition and Metabolism Research, Korea Food Research Institute)
Journal
한국응용생명화학회 Applied Biological Chemistry Applied Biological Chemistry 제59권 제5호 KCI Accredited Journals SCOPUS
Published
2016.1
Pages
775 - 780 (6page)

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Mass spectrometry-based metabolomic study of traditional Doenjang effects against hepatic fibrosis
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Abstract· Keywords

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Korean traditional Doenjang are currently certified as traditional food. Certified Doenjang are valuable as a traditional food, however, only a few studies have evaluated and researched their quality characteristics and functionality. In the present study, we investigated the metabolite profile of Doenjang according to its ${\alpha}$-SMA expression suppressing effect through mass spectrometry-based metabolomics. Also, the relationship between Doenjang metabolites and the suppression of ${\alpha}$-SMA expression was identified. In the efforts to find traditional Doenjang metabolites related to liver functions, branched-chain amino acids, p-aminobenzoic acid, 7,4'-dihydroxyflavone, soyasaponin, and isoflavone aglycone were found to be higher in the Doenjang group and showed higher ${\alpha}$-SMA expression suppression activity. The present study highlights the fact that comprehensive metabolite analysis of traditional Doenjang provides information on its ability to improve liver function as well as other useful information for better understanding of the factors related to the effects of Doenjang metabolites against hepatic fibrosis.
#${alpha}$-SMA expression inhibiting activity #Doenjang #MS-based metabolomics

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