지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 313 - 321 (9page)
이용수
초록· 키워드
오류제보하기
Anti-cancer drug resistance is a major problem in colorectal cancer (CRC) research. Although several studies have revealed the mechanism of cancer drug resistance, molecular targets for chemotherapeutic combinations remain elusive. To address this issue, we focused on the expression of cellular prion protein ($PrP^C$) in 5-FU-resistant CRC cells. In 5-FU-resistant CRC cells, $PrP^C$ expression is significantly increased, compared with that in normal CRC cells. In the presence of 5-FU, $PrP^C$ increased CRC cell survival and proliferation by maintaining the activation of the PI3K-Akt signaling pathway and the expression of cell cycle-associated proteins, including cyclin E, CDK2, cyclin D1, and CDK4. In addition, $PrP^C$ inhibited the activation of the stress-associated proteins p38, JNK, and p53. Moreover, after treatment of 5-FU-resistant CRC cells with 5-FU, silencing of $PrP^C$ triggered apoptosis via the activation of caspase-3. These results indicate that $PrP^C$ plays a key role in CRC drug resistance. The novel strategy of combining chemotherapy with $PrP^C$ targeting may yield efficacious treatments of colorectal cancer.
목차
등록된 정보가 없습니다.
참고문헌 (34)
참고문헌 신청
Adelstein, D. J. / 2006 / Multiagent concurrent chemoradiotherapy for locoregionally advanced squamous cell head and neck cancer: mature results from a single institution / J. Clin. Oncol. 24:1064~1071
Alvarez, P. / 2012 / 5-Fluorouracil derivatives: a patent review / Expert Opin. Ther. Pat. 22:107~123
Brown, D. R. / 1997 / Prion protein-deficient cells show altered response to oxidative stress due to decreased SOD-1 activity / Exp. Neurol. 146:104~112
Cheng, Y. / 2014 / CD44/cellular prion protein interact in multidrug resistant breast cancer cells and correlate with responses to neoadjuvant chemotherapy in breast cancer patients / Mol. Carcinog. 53:686~697
Du, L. / 2013 / CD44-positive cancer stem cells expressing cellular prion protein contribute to metastatic capacity in colorectal cancer / Cancer Res. 73:2682~2694
Alvarez, P. / 2012 / 5-Fluorouracil derivatives: a patent review / Expert Opin. Ther. Pat. 22:107~123
Brown, D. R. / 1997 / Prion protein-deficient cells show altered response to oxidative stress due to decreased SOD-1 activity / Exp. Neurol. 146:104~112
Cheng, Y. / 2014 / CD44/cellular prion protein interact in multidrug resistant breast cancer cells and correlate with responses to neoadjuvant chemotherapy in breast cancer patients / Mol. Carcinog. 53:686~697
Du, L. / 2013 / CD44-positive cancer stem cells expressing cellular prion protein contribute to metastatic capacity in colorectal cancer / Cancer Res. 73:2682~2694
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Attitudes Towards Colorectal Cancer (CRC) and CRC Screening Tests among Elderly Malay Patients
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Microarray Analysis of Long Non-coding RNA Expression Profile Associated with 5-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
대장암 동물 모델에 대한 이해
의생명과학
2018 .01
-
MicroRNA-362 Inhibits Cell Proliferation and Invasion by Directly Targeting SIX1 in Colorectal Cancer
Yonsei Medical Journal
2019 .01
-
Freeze-Dried Platelet-Rich Plasma Induces Osteoblast Proliferation via Platelet-Derived Growth Factor Receptor-Mediated Signal Transduction
Asian Spine Journal
2020 .01
-
Chasm between Public Perceptions and Epidemiological Data on Colorectal Cancer
Gut and Liver
2023 .05
-
Prospective Clinical Research of the Efficacy of Platelet-rich Plasma in the Outpatient-based Treatment of Rotator Cuff Tendinopathy
대한견주관절의학회지
2019 .06
-
Clinical and Biological Features of Interval Colorectal Cancer
Clinical Endoscopy
2017 .01
-
The Early Histological Effects of Intravesical Instillation of Platelet- Rich Plasma in Cystitis Models
International Neurourology Journal
2016 .01
-
Characteristics of Young Colorectal Cancer in Brunei Darussalam: an Epidemiologic Study of 29 Years (1986-2014)
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Assessment of Jordanian Patient's Colorectal Cancer Awareness and Preferences towards CRC Screening: Are Jordanians Ready to Embrace CRC Screening?
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Epithelial-mesenchymal Transition is Associated with Acquired Resistance to 5-Fluorocuracil in HT-29 Colon Cancer Cells
Toxicological Research
2015 .06
-
Knowledge and Perceptions about Colorectal Cancer in Jordan
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
CXCL-13 Regulates Resistance to 5-Fluorouracil in Colorectal Cancer
Cancer Research and Treatment
2020 .01
-
Unraveling molecular similarities between colorectal polyps and colorectal cancer: a systems biology approach
Intestinal research
2024 .04
-
Current Colorectal Cancer in Thailand
Annals of Coloproctology
2020 .01
-
Potential Benefit of Metformin as Treatment for Colon Cancer: the Evidence so Far
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Rhein suppresses colorectal cancer cell growth by inhibiting the mTOR pathway in vitro and in vivo
한국실험동물학회 학술발표대회 논문집
2021 .07
-
Risk Factors for Colorectal Cancer in Thailand
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Histologic Evidence of New Collagen Formulation Using Platelet Rich Plasma in Skin Rejuvenation: A Prospective Controlled Clinical Study
Annals of Dermatology
2016 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0