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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 27 - 34 (8page)
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Curcumin is naturally occurring polyphenolic compound found in turmeric and has many pharmacological activities. The present study was undertaken to evaluate anti-allergic inflammatory activity of curcumin, and to investigate its inhibitory mechanisms in immunoglobulin E (IgE)/Ag-induced mouse bone marrow-derived mast cells (BMMCs) and in a mouse model of IgE/Ag-mediated passive systemic anaphylaxis (PSA). Curcumin inhibited cyclooxygenase-2 (COX-2) dependent prostaglandin $D_2$ ($PGD_2$) and 5-lipoxygenase (5-LO) dependent leukotriene $C_4$ ($LTC_4$) generation dose-dependently in BMMCs. To probe the mechanism involved, we assessed the effects of curcumin on the phosphorylation of Syk and its downstream signal molecules. Curcumin inhibited intracellular $Ca^{2+}$ influx via phospholipase $C{\gamma}1$ ($PLC{\gamma}1$) activation and the phosphorylation of mitogen-activated protein kinases (MAPKs) and the nuclear factor-${\kappa}B$ (NF-${\kappa}B$) pathway. Furthermore, the oral administration of curcumin significantly attenuated IgE/Ag-induced PSA, as determined by serum $LTC_4$, $PGD_2$, and histamine levels. Taken together, this study shows that curcumin offers a basis for drug development for the treatment of allergic inflammatory diseases.
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참고문헌 (39)
참고문헌 신청
Ammon, H. P / 1991 / Pharmacology of Curcuma longa / Planta Med 57:1~7
Ashraf, M / 1996 / Cross-linking of the highaffinityIgE receptor induces the expression of cyclo-oxygenase2 and attendant prostaglandin generation requiring interleukin 10and interleukin 1 beta in mouse cultured mast cells / Biochem. J 320:965~973
Avis, I / 2001 / Five-lipoxygenase inhibitorscan mediate apoptosis in human breast cancer cell linesthrough complex eicosanoid interactions / FASEB J 15:2007~2009
Cho, J. W / 2007 / Curcumin attenuates theexpression of IL-1β, IL-6, and TNF-α as well as cyclin E in TNF-α-treated HaCaT cells; NF-κB and MAPKs as potential upstreamtargets. Int. J. Mol. Med / Int. J. Mol. Med 19:469~474
최윤호 / 2010 / Inhibitory effects of curcumin on passive cutaneous anaphylactoid response and compound 48/80-induced mast cell activation / Anatomy and Cell Biology 43(1):36~43
Ashraf, M / 1996 / Cross-linking of the highaffinityIgE receptor induces the expression of cyclo-oxygenase2 and attendant prostaglandin generation requiring interleukin 10and interleukin 1 beta in mouse cultured mast cells / Biochem. J 320:965~973
Avis, I / 2001 / Five-lipoxygenase inhibitorscan mediate apoptosis in human breast cancer cell linesthrough complex eicosanoid interactions / FASEB J 15:2007~2009
Cho, J. W / 2007 / Curcumin attenuates theexpression of IL-1β, IL-6, and TNF-α as well as cyclin E in TNF-α-treated HaCaT cells; NF-κB and MAPKs as potential upstreamtargets. Int. J. Mol. Med / Int. J. Mol. Med 19:469~474
최윤호 / 2010 / Inhibitory effects of curcumin on passive cutaneous anaphylactoid response and compound 48/80-induced mast cell activation / Anatomy and Cell Biology 43(1):36~43
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