지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 342 - 348 (7page)
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초록· 키워드
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Ossification of the posterior longitudinal ligament (OPLL) can be defined as an ectopic ossification in the tissues of spinal ligament showing a hyperostotic condition. OPLL is developed mostly in the cervical spine and clinical presentations of OPLL are majorly myelopathy and/or radiculopathy, with serious neurological pathology resulting in paralysis of extremities and disturbances of motility lowering the quality of life. OPLL is known to be an idiopathic and multifactorial disease, which genetic factors and non-genetic factors including diet, obesity, physical strain on the posterior longitudinal ligament, age, and diabetes mellitus, are involved into the pathogenesis. Up to now, surgical management by decompressing the spinal cord is regarded as standard treatment for OPLL, although there might be the risk of development of reprogression of ossification. The molecular pathogenesis and efficient therapeutic strategy, especially pharmacotherapy and/or preventive intervention, of OPLL has not been clearly elucidated and suggested. Therefore, in this review, we tried to give an overview to the present research results on OPLL, in order to shed light on the potential pharmacotherapy based on molecular pathophysiologic aspect of OPLL, especially on the genetic/genomic factors involved into the etiology of OPLL.
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등록된 정보가 없습니다.
참고문헌 (90)
참고문헌 신청
Abiola R / 2016 / Ossification of the posterior longitudinal ligament : etiology, diagnosis, and outcomes of non-operative and operative management / Global Spine J 6:195~204
Toru Akune / 2001 / Insulin Secretory Response Is Positively Associated With the Extent of Ossification of the Posterior Longitudinal Ligament of the Spine / The Journal of Bone and Joint Surgery-American Volume 83(10):1537~1544
Asari T / 2012 / Mesenchymal stem cell isolation and characterization from human spinal ligaments / Biochem Biophys Res Commun 417:1193~1199
범재영 / 2018 / The Need for Early Tracheostomy in Patients with Traumatic Cervical Cord Injury / Clinics in Orthopedic Surgery 10(2):191~196
Bonewald LF / 1994 / Role of active and latent transforming growth factor beta in bone formation / J Cell Biochem 55:350~357
Toru Akune / 2001 / Insulin Secretory Response Is Positively Associated With the Extent of Ossification of the Posterior Longitudinal Ligament of the Spine / The Journal of Bone and Joint Surgery-American Volume 83(10):1537~1544
Asari T / 2012 / Mesenchymal stem cell isolation and characterization from human spinal ligaments / Biochem Biophys Res Commun 417:1193~1199
범재영 / 2018 / The Need for Early Tracheostomy in Patients with Traumatic Cervical Cord Injury / Clinics in Orthopedic Surgery 10(2):191~196
Bonewald LF / 1994 / Role of active and latent transforming growth factor beta in bone formation / J Cell Biochem 55:350~357
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Analysis of Factors Contributing to Repeat Surgery in Multi-Segments Cervical Ossification of Posterior Longitudinal Ligament
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Selective Angiography to Detect Anterior Spinal Artery Stenosis in Thoracic Ossification of the Posterior Longitudinal Ligament
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Variations in Practice among Asia–Pacific Surgeons and Recommendations for Managing Cervical Myelopathy: The First Asia–Pacific Spine Society Collaborative Study
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Arteriovenous Fistula at the Craniocervical Junction Found After Cervical Laminoplasty for Ossification of the Posterior Longitudinal Ligament
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Investigation of Symptomatic Unstable Changes of Non-Fused Component in the Mixed-Type Cervical Ossifcation of Posterior Longitudinal Ligament Using Dynamic Magnetic Resonance Imaging: A Case Report
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The R-line: A New Imaging Index for Decision Making Regarding C2 Lamina Decompression in Cervical Ossifcation of the Posterior Longitudinal Ligament
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Use of an Ultrasonic Osteotome for Direct Removal of Beak-Type Ossification of Posterior Longitudinal Ligament in the Thoracic Spine
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Assessment of Cervical Myelopathy Risk in Ossification of the Posterior Longitudinal Ligament Patients With Spinal Cord Compression Based on Segmental Dynamic Versus Static Factors
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