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자료유형
학술저널
저자정보
Qian, Yu (Department of Biological and Chemical Engineering, Chongqing University of Education) Li, Guijie (Department of Biological and Chemical Engineering, Chongqing University of Education) Zhu, Kai (Department of Biological and Chemical Engineering, Chongqing University of Education) Sun, Peng (Department of Biological and Chemical Engineering, Chongqing University of Education) Feng, Xia (Department of Biological and Chemical Engineering, Chongqing University of Education) Zhao, Xin (Department of Biological and Chemical Engineering, Chongqing University of Education)
저널정보
한국응용생명화학회 Applied Biological Chemistry Applied Biological Chemistry 제56권 제5호
발행연도
2013.1
수록면
613 - 619 (7page)

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Three types of resistant starch (RS) products were purchased for the evaluation of gastric injury preventive effect in Sprague-Dawley rats. We used an animal model to check for gastric injury preventive activities of these RS products in vivo. RS3 reduced the levels of serum proinflammatory cytokines of IL-6 and TNF-${\alpha}$ as compared to those of RS2 and RS4. The gastric secretion volumes from high to low order were control rats, RS2-treated rats, RS4-treated rats, RS3-treated rats, and normal rats, whereas pH levels of gastric juice showed the opposite trend. The gastric injury level was significantly decreased by RS, demonstrating its anti-inflammatory properties, with RS3 showing the best anti-inflammatory effect. Gastric tissues of RS3 group rats showed significantly decreased mRNA and protein expression levels of inflammation-related genes of iNOS, COX-2, TNF-${\alpha}$, and IL-$1{\beta}$ compared with the control group, as shown by RT-PCR and Western blot analyses. These results suggest that RS shows a gastric injury preventive effect, with RS3 showing the best inhibitory effect on gastric injury.

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