지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 251 - 257 (7page)
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초록· 키워드
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Inflammatory skin diseases such as atopic dermatitis (AD) and rosacea were complicated by barrier abrogation and deficiency in innate immunity. The first defender of epidermal innate immune response is the antimicrobial peptides (AMPs) that exhibit a broad-spectrum antimicrobial activity against multiple pathogens, including Gram-positive and Gram-negative bacteria, viruses, and fungi. The deficiency of these AMPs in the skin of AD fails to protect our body against virulent pathogen infections. In contrast to AD where there is a suppression of AMPs, rosacea is characterized by overexpression of cathelicidin antimicrobial peptide (CAMP), the products of which result in chronic epidermal inflammation. In this regard, AMP generation that is controlled by a key ceramide metabolite S1P-dependent mechanism could be considered as alternate therapeutic approaches to treat these skin disorders, i.e., Increased S1P levels strongly stimulated the CAMP expression which elevated the antimicrobial activity against multiple pathogens resulting the improved AD patient skin.
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등록된 정보가 없습니다.
참고문헌 (66)
참고문헌 신청
Ahn, J. K. / 2013 / The role of alpha-defensin-1 and related signal transduction mechanisms in the production of IL-6, IL-8 and MMPs in rheumatoid fi broblast-like synoviocytes / Rheumatology (Oxford) 52:1368~1376
Ali, R. S. / 2001 / Expression of the peptide antibiotics human beta defensin-1 and human beta defensin-2 in normal human skin / J. Invest. Dermatol 117:106~111
Arik awa, J. / 2002 / Decreased levels of sphingosine, a natural antimicrobial agent, may be associated with vulnerability of the stratum corneum from patients with atopic dermatitis to colonization by Staphylococcus aureus / J. Invest. Dermatol 119:433~439
Bage lla, L. / 1995 / cDNA sequences of three sheep myeloid cathelicidins / FEBS Lett 376:225~228
Bals, R. / 2001 / Rhesus monkey (Macaca mulatta) mucosal antimicrobial peptides are close homologues of human molecules / Clin. Diagn. Lab. Immunol 8:370~375
Ali, R. S. / 2001 / Expression of the peptide antibiotics human beta defensin-1 and human beta defensin-2 in normal human skin / J. Invest. Dermatol 117:106~111
Arik awa, J. / 2002 / Decreased levels of sphingosine, a natural antimicrobial agent, may be associated with vulnerability of the stratum corneum from patients with atopic dermatitis to colonization by Staphylococcus aureus / J. Invest. Dermatol 119:433~439
Bage lla, L. / 1995 / cDNA sequences of three sheep myeloid cathelicidins / FEBS Lett 376:225~228
Bals, R. / 2001 / Rhesus monkey (Macaca mulatta) mucosal antimicrobial peptides are close homologues of human molecules / Clin. Diagn. Lab. Immunol 8:370~375
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