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학술저널
저자정보
Lee, Sangkook (Department of Neurosurgery, Hanyang University Guri Hospital, Hanyang University College of Medicine) Cheong, Jinhwan (Department of Neurosurgery, Hanyang University Guri Hospital, Hanyang University College of Medicine) Kim, Choonghyun (Department of Neurosurgery, Hanyang University Guri Hospital, Hanyang University College of Medicine) Kim, Jae Min (Department of Neurosurgery, Hanyang University Guri Hospital, Hanyang University College of Medicine)
저널정보
대한신경외과학회 대한신경외과학회지 대한신경외과학회지 제58권 제2호
발행연도
2015.1
수록면
159 - 162 (4page)

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Neurological deficits after brain surgery are not uncommon, and correct and prompt differential diagnosis is essential to initiate appropriate treatment. We describe a patient suffering from loss of consciousness due to hyperammonemia, following valproic acid treatment after surgery for an unruptured cerebral aneurysm. A 57-year-old female patient underwent successful aneurysmal neck clipping to correct an unruptured aneurysm. Her postoperative course was good, and she received anti-epileptic therapy (valproic acid) and a soft diet. Within a few days the patient experienced mental deterioration. Her serum valproic acid reached toxic levels (149.40 mg/L), and serum ammonia was fifteen times the upper normal limit (553 mmol/L; normal range, 9-33 mmol/L). After discontinuation of valproic acid and with conservative treatment, the patient recovered without any complications. Valproate-induced hyperammonemic encephalopathy is an unusual but serious neurosurgical complication, and should not be disregarded as a possible cause of neurological deficits after neurovascular surgery. Early diagnosis is crucial, as discontinuation of valproic acid therapy can prevent serious complications, including death.

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