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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 398 - 410 (13page)
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초록· 키워드
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Over the past few decades, our understanding of the epidemiology and immunopathogenesis of Hodgkin lymphoma (HL) has made enormous advances. Consequently, the treatment of HL has changed significantly, rendering this disease of the most curable human cancers. To date, about 80% of patients achieve long-term disease-free survival. However, therapeutic challenges still remain, particularly regarding the salvage strategies for relapsed and refractory disease, which need further identification of better prognostic markers and novel therapeutic schemes. Although the precise molecular mechanism by which Epstein-Barr virus (EBV) contributes to the generation of malignant cells present in HL still remains unknown, current increasing data on the role of EBV in the pathobiology of HL have encouraged people to start developing novel and specific therapeutic strategies for EBV-associated HL. This review will provide an overview of therapeutic approaches for acute EBV infection and the classical form of HL (cHL), especially focusing on EBV-associated HL cases.
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참고문헌 (175)
참고문헌 신청
Adams, J / 2003 / Potential for proteasome inhibition in the treatment of cancer / Drug Discov. Today 8:307~315
Aldinucci, D / 2010 / The classical Hodgkin's lymphoma microenvironment and its role in promoting tumour growth and immune escape / J. Pathol 221:248~263
Ambinder, R. F / 1993 / Epstein-Barr virus and childhood Hodgkin's disease in Honduras and the United States / Blood 81:462~467
Anderson, L. J / 2008 / An auto-regulatory loop for EBV LMP2A involves activation of Notch / Virology 371:257~266
Ansell, S. M / 2007 / Phase I/II study of an anti-CD30 monoclonal antibody (MDX-060) in Hodgkin's lymphoma and anaplastic large-cell lymphoma / J. Clin. Oncol 25:2764~2769
Aldinucci, D / 2010 / The classical Hodgkin's lymphoma microenvironment and its role in promoting tumour growth and immune escape / J. Pathol 221:248~263
Ambinder, R. F / 1993 / Epstein-Barr virus and childhood Hodgkin's disease in Honduras and the United States / Blood 81:462~467
Anderson, L. J / 2008 / An auto-regulatory loop for EBV LMP2A involves activation of Notch / Virology 371:257~266
Ansell, S. M / 2007 / Phase I/II study of an anti-CD30 monoclonal antibody (MDX-060) in Hodgkin's lymphoma and anaplastic large-cell lymphoma / J. Clin. Oncol 25:2764~2769
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