지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 431 - 437 (7page)
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초록· 키워드
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Aberrant activation of microglia has been reported to cause neuronal damages by releasing a variety of pro-inflammatory cytokines. Besides where microglia become active, damages have been also observed in remote places, which is considered due to the migration of activated microglia. Therefore, an agent that could suppress abnormal activation of microglia and their subsequent migration might be valuable in activated microglia-related brain pathologies. The objective of the present study was to evaluate anti-inflammatory effects of betulinic acid on lipopolysaccharide (LPS)-stimulated BV2 microglial cells. Pretreatment of betulinic acid significantly attenuated LPS-induced NO production and protein expression of iNOS. Betulinic acid also significantly suppressed LPS-induced release and expression of cytokines such as TNF-${\alpha}$ and IL-$1{\beta}$. Furthermore, betulinic acid significantly uppressed LPS-induced MMP-9 expression, which has been suggested to play an important role in the migration of activated microglia. In order to understand the possible mechanism by which betulinic acid suppresses LPS-induced cytokine production and migration of microglia, the role of NF-kB, a major pro-inflammatory transcription factor, was examined. Betulinic acid significantly suppressed LPS-induced degradation of IKB, which retains NF-kB in the cytoplasm. Therefore, nuclear translocation of NF-kB upon LPS stimulation was significantly suppressed with betulinic acid. Taken together, the present study for the first time demonstrates that betulinic acid possesses anti-inflammatory activity through the suppression of nuclear translocation of NF-kB in BV2 microglial cells.
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참고문헌 (39)
참고문헌 신청
Aquilano, K / 2008 / Role of nitric oxide synthases in Parkinson's disease: a review on the antioxidant and anti-infl ammatory activity of polyphenols / Neurochem. Res 33:2416~2426
Bonizzi, G / 2004 / The two NF-kappaB activation pathways and their role in innate and adaptive immunity / Trends Immunol 25:280~288
Chao, C. C / 1992 / Cytokine release from microglia: differential inhibition by pentoxifylline and dexamethasone / J. Infect Dis 166:847~853
Chintharlapalli, S / 2007 / Betulinic acid inhibits prostate cancer growth through inhibition of specifi city protein transcription factors / Cancer Res 67:2816~2823
Cho, I. H. / 2008 / Role of microglial IKKbeta in kainic acid-induced hippocampal neuronal cell death / Brain 131:3019~3033
Bonizzi, G / 2004 / The two NF-kappaB activation pathways and their role in innate and adaptive immunity / Trends Immunol 25:280~288
Chao, C. C / 1992 / Cytokine release from microglia: differential inhibition by pentoxifylline and dexamethasone / J. Infect Dis 166:847~853
Chintharlapalli, S / 2007 / Betulinic acid inhibits prostate cancer growth through inhibition of specifi city protein transcription factors / Cancer Res 67:2816~2823
Cho, I. H. / 2008 / Role of microglial IKKbeta in kainic acid-induced hippocampal neuronal cell death / Brain 131:3019~3033
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